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中国药物评价 ›› 2026, Vol. 43 ›› Issue (3): 222-222-225.doi: 10.2095-3593.2026.050002

• 临床研究 • 上一篇    下一篇

补中益气汤在混合痔术后创面愈合中的应用观察

邹梦1, 罗曹园2, 梁思洁1, 吴文江1*   

  1. 1.广州中医药大学深圳医院, 广东 深圳 518000;
    2.深圳福田区妇幼保健院, 广东 深圳 518000
  • 收稿日期:2026-03-20 修回日期:2026-04-15 接受日期:2026-05-19 出版日期:2026-06-28 发布日期:2026-08-12
  • 基金资助:
    广州中医药大学校院联合科技创新基金-深圳医院基金项目(GZYFT2024G14)

Observation on the Application of Buzhong Yiqi Decoction in Wound Healing after Mixed Hemorrhoid Surgery

ZOU Meng1, LUO Caoyuan2, LIANG Sijie1, WU Wenjiang1*   

  1. 1.Shenzhen Hospital of Guangzhou University of Chinese Medicine, Guangdong Shenzhen 518000, China;
    2.Maternity & Child Health-care Hospital of Futian District, Guangdong Shenzhen 518000, China
  • Received:2026-03-20 Revised:2026-04-15 Accepted:2026-05-19 Online:2026-06-28 Published:2026-08-12

摘要: 目的:探讨补中益气汤对混合痔术后创面愈合的疗效。方法:选取某院2022年12月至2025年12月入院的100例混合痔术后患者作为研究对象,采用随机数字表法将其分为两组,每组各50例;其中对照组采用常规治疗方案,研究组则在常规治疗基础上联合补中益气汤进行干预。结果:治疗后,研究组中医证候积分[主症(1.32±0.11)分、次症(0.92±0.16)分]、肛门功能指标[肛管收缩压(114.19±10.24)mmHg、肛管静息压(39.02±5.07)mmHg、Wexner便秘评分(11.06±2.18)分]均低于对照组(P<0.05);研究组创面愈合情况[出血评分(0.59±0.14)分、分泌物评分(0.80±0.23)分、愈合时间(20.40±4.64)d]、创面因子水平[bFGF(67.23±10.03)ng·L-1、VEGF(115.15±18.42)ng·L-1、PDGF(57.08±12.17)ng·L-1]均优于对照组(P<0.05);研究组炎性因子水平[IL-6(45.20±8.33)μg·L-1、hs-CRP(16.53±3.34)mg·L-1]、并发症发生率(2.00%)均低于对照组(P<0.05)。结论:补中益气汤可改善混合痔术后患者肛门功能、炎性因子水平及中医症候积分,对创面修复有积极意义。

关键词: font-size:medium, ">混合痔;补中益气汤;肛门功能;中医症候积分;炎性因子;并发症;创面因子

Abstract: Objective: To investigate the effect of buzhong yiqi decoction on wound healing after mixed hemorrhoid surgery. Methods: From December 2022 to December 2025, 100 patients after mixed hemorrhoids surgery were selected as the research subjects. The patients were divided into two groups using the random number table method, with 50 cases in each group. The control group received conventional treatment and the study group received conventional treatment combined with Buzhong Yiqi decoction). Results: After treatment the TCM syndrome scores [main symptoms (1.32±0.11), secondary symptoms (0.92±0.16)] and anal function indexes [anal canal systolic pressure (114.19±10.24)mmHg, anal canal resting pressure (39.02±5.07)mmHg, Wexner constipation score (11.06±2.18)] in the study group were lower than those in the control group (P<0.05). Wound healing conditions [bleeding score (0.59±0.14), secretion score (0.80±0.23), healing time (20.40±4.64) d] and wound healing factor levels [bFGF (67.23±10.03)ng·L-1, VEGF (115.15±18.42)ng·L-1, PDGF(57.08±12.17)ng·L-1] in the study group were significantly better than those in the control group (P<0.05). The inflammatory factor levels [IL-6 (45.20±8.33)μg·L-1, hs-CRP(16.53±3.34)mg·L-1] and incidence of complications rate (2.00%) in the study group were lower than those in the control group (P<0.05). Conclusion: Buzhong yiqi decoction can improve anal function, inflammatory factors level and TCM syndrome scores of patients after mixed hemorrhoid surgery, and has positive significance for wound repair.

Key words: font-size:medium, ">Mixed hemorrhoids; Buzhong yiqi decoction; Anal function; TCM syndrome scores; Inflammatory factors; Complications; Wound healing factors

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