<span style="font-family:&quot;font-size:medium;">丙泊酚与磷丙泊酚二钠在成人无痛胃肠镜</span><span style="font-family:&quot;font-size:medium;">中应用的比较研究</span>

徐传果, 杨朋朋, 陈振娟, 赵学亮

doi:magtech-2025-09-19-00002

中国药物评价 >

2025 , Vol. 42 >Issue 5: 384 - 384-388

DOI: https://doi.org/magtech-2025-09-19-00002

临床研究

丙泊酚与磷丙泊酚二钠在成人无痛胃肠镜中应用的比较研究

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1.泰安市妇幼保健院，山东泰安 271000；
2.山东第一医科大学第二附属医院，山东泰安 271000；
3.泰安市中医二院，山东泰安 271000

徐传果，男，副主任医师，研究方向：临床麻醉

收稿日期: 2025-09-19

修回日期: 2025-10-10

录用日期: 2025-11-27

网络出版日期: 2025-12-15

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Propofol versus Fospropofol Disodium for Painless Gastrointestinal Endoscopy in Adults

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1.Tai′an Maternal and Child Health Hospital， Shandong Tai′an 271000， China；
2.The Second Affiliated Hospital of Shandong First Medical University， Shandong Tai′an 271000， China；
3.The Second Traditional Chinese Medicine Hospital of Tai′an， Shandong Tai′an 271000， China

Received date: 2025-09-19

Revised date: 2025-10-10

Accepted date: 2025-11-27

Online published: 2025-12-15

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摘要

目的：探讨磷丙泊酚二钠与丙泊酚在成人无痛胃肠镜麻醉中的效果与安全性差异，重点分析磷丙泊酚二钠在降低呼吸抑制及注射疼痛方面的潜在优势，为不同风险等级患者的麻醉药物选择提供依据。方法：采用随机对照研究方法，纳入2023年10月至2024年12月间于我院行无痛胃肠镜检查的80例ASA Ⅰ~Ⅱ级成人患者。按照随机数字表法分为两组：丙泊酚组（A组，40例）与磷丙泊酚二钠组（B组，40例）。比较两组患者检查持续时间、苏醒及离室时间，监测麻醉前后各时点血压、心率、血氧饱和度等指标，并统计低血压、呼吸抑制、注射痛及其他不良事件的发生率。结果：两组患者在检查持续时间方面差异无统计学意义（P>0.05）；B组患者的苏醒时间及苏醒室停留时间均明显短于A组（P<0.001）。在麻醉诱导及维持阶段（T1、T2、T3），B组平均动脉压、心率水平均显著高于A组（P<0.05）。B组患者发生低血压、呼吸抑制及注射痛的比例较A组明显减少（P<0.05），但两组在恶心呕吐、心动过缓及咳嗽发生率方面差异差异均无统计学意义（P>0.05）。进一步分析显示，预防1例呼吸抑制所需治疗人数（NNT）为5，每1000名患者可减少约200例相关事件。结论：相较于传统丙泊酚，磷丙泊酚二钠在成人无痛胃肠镜麻醉中表现出更佳的血流动力学稳定性，并可显著降低呼吸抑制与注射疼痛的风险。该药物对ASA Ⅰ~Ⅱ级且存在呼吸功能风险的患者尤为适用，但临床应用仍应根据个体特征及手术需求进行综合评估与选择。

关键词： ; font-size:medium; ">丙泊酚；磷丙泊酚二钠；成人无痛胃肠镜；随机对照试验

本文引用格式

徐传果, 杨朋朋, 陈振娟, 赵学亮 . 丙泊酚与磷丙泊酚二钠在成人无痛胃肠镜中应用的比较研究[J]. 中国药物评价, 2025 , 42(5) : 384 -384-388 . DOI: magtech-2025-09-19-00002

Abstract

Objective： To compare the efficacy and safety of fospropofol disodium versus propofol for anesthesia in adult patients undergoing painless gastrointestinal endoscopy， focusing onthe potential of fospropofol disodium to reduce respiratory depression and injection pain， and to guide anesthetic selection in patients with differing risk profiles. Methods： In this randomized controlled trial， 80 adult patients (ASA physical status Ⅰ-Ⅱ) scheduled for painless gastrointestinal endoscopy between October 2023 and December 2024 were enrolled. They were randomly assigned via a computer-generated random number table to receive either propofol (Group A， n=40) or fospropofol disodium (Group B， n=40). We compared the procedure duration， recovery time， and time to discharge from the post-anesthesia care unit (PACU). Hemodynamic parameters， including blood pressure， heart rate， and oxygen saturation (SpO2)， were monitored at predefined time points. The incidence of adverse events such as hypotension， respiratory depression， and injection pain was recorded and statistically analyzed. Results： No significant intergroup difference was found in procedure duration (P>0.05). However， Group B exhibited significantly shorter recovery time and PACU discharge time than Group A (P<0.001). During anesthesia induction and maintenance (T1， T2， T3)， mean arterial pressure， heart rate levels were significantly higher in Group B (P<0.05). The incidence of hypotension， respiratory depression， and injection pain was significantly lower in Group B (P<0.05). In contrast， the rates of nausea and vomiting， bradycardia， and coughing did not differ significantly between groups (P>0.05). Further analysis indicated a number needed to treat (NNT) of 5 to prevent one case of respiratory depression， equating to approximately 200 fewer events per 1000 patients. Conclusion： Compared with propofol， fospropofol disodium provides superior hemodynamic stability and significantly reduces the incidence of respiratory depression and injection pain during painless gastrointestinal endoscopy in adults. Althoughit is particularly suitable for ASA Ⅰ-Ⅱ patients at risk of respiratory compromise， the final selection should be individualized based on patient characteristics and procedural requirements.

Key words： ; font-size:medium; ">Propofol； Fospropofol disodium； Painless gastrointestinal endoscopy； Randomized controlled trial

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