中药提取物在皮肤色素沉着治疗中的研究进展

周津羽; 刘奕娴; 李珍玉; 黄冬强

doi:magtech-2025-07-11-00002

中国药物评价 >

2025 , Vol. 42 >Issue 6: 453 - 453-459

DOI: https://doi.org/magtech-2025-07-11-00002

药物研究

中药提取物在皮肤色素沉着治疗中的研究进展

周津羽 ,
刘奕娴 ,
李珍玉 ,
黄冬强

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海南省药品和医疗器械审评服务中心，海南海口 570216

周津羽，女，硕士，研究方向：药品审评工作

收稿日期: 2025-07-11

修回日期: 2025-10-10

录用日期: 2026-01-07

网络出版日期: 2026-01-07

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Research Advances of Traditional Chinese Medicine Extracts in the Treatment of Skin Pigmentation

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Hainan Center for Drug and Medical Device Evaluation and Service， Hainan Haikou 570216， China

Received date: 2025-07-11

Revised date: 2025-10-10

Accepted date: 2026-01-07

Online published: 2026-01-07

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摘要

皮肤色素沉着是一种普遍存在的皮肤现象，其核心机制在于黑色素合成与信号通路的异常活化。靶向抑制酪氨酸酶等关键限速酶的催化活性，有效阻断促黑信号通路如α-MSH-MC1R、SCF-c-Kit的转导，是干预色素异常沉积的关键策略。研究表明，传统中药蕴含丰富的生物活性物质，在调控色素沉着方面展现出显著潜力。代表性提取物如白芍中的芍药苷、甘草中的甘草素及当归中的阿魏酸等，在抑制酪氨酸酶活性、调控黑色素细胞代谢中发挥重要作用。本研究系统归纳了色素沉着的作用机制及中药提取物活性成分的研究进展，旨在为开发中药美白化妆品原料提供理论依据与应用支持。

关键词： ; font-size:medium; ">中药提取物；色素沉着；研究进展；中药治疗

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周津羽 , 刘奕娴 , 李珍玉 , 黄冬强 . 中药提取物在皮肤色素沉着治疗中的研究进展[J]. 中国药物评价, 2025 , 42(6) : 453 -453-459 . DOI: magtech-2025-07-11-00002

Abstract

Skin pigmentation is a prevalent dermatological condition， the underlying mechanism of which is the aberrant activation of melanin synthesis and signalling pathways. The most effective strategies for intervening in abnormal pigment deposition involve targeted inhibition of the catalytic activity of key rate-limiting enzymes， such as tyrosinase， and effective blockade of the transduction of pro-melanotic signalling pathways， such as α-MSH-MC1R and SCF-c-Kit. Research has indicated that Traditional Chinese Medicines (TCM) are abundant in bioactive substances and possess considerable potential in modulating pigmentation. Representative extracts， including paeoniflorin in Paeonia lactiflora and glycyrrhizin in Glycyrrhiza and ferulic acid in Angelica sinensis， have been shown to play important roles in inhibiting tyrosinase activity and regulating melanocyte metabolism.This paper systematically summarises the mechanism of action of pigmentation， as well as the progress of research on the active constituents of traditional Chinese medicine extracts， thereby providing a theoretical foundation and potential avenues for future research and application in the field of TCM whitening cosmetic raw materials.

Key words： ; font-size:medium; "> ; TCM extracts； Pigmentation； Research progress； Chinese herbal medicine treatment

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