医用镁基材料表面改性技术的研究进展与应用展望

曲春鸽; 江珊; 尤茗语; 田甜

doi:10.2095-3593.2026.030002

中国药物评价 >

2026 , Vol. 43 >Issue 1: 9 - 9-13

DOI: https://doi.org/10.2095-3593.2026.030002

医用镁基材料表面改性技术的研究进展与应用展望

曲春鸽 ,
江珊 ,
尤茗语 ,
田甜

展开

国家药品监督管理局医疗器械技术审评检查长三角分中心，上海 201210

曲春鸽，女，工程师，研究方向：无源医疗器械技术审评

收稿日期: 2025-09-15

修回日期: 2025-10-16

录用日期: 2026-04-01

网络出版日期: 2026-04-01

基金资助

上海市科学技术委员会项目（24692122800）

收起

Surface Modification of Medical Magnesium-Based Materials： Advances and Perspectives

Expand

Yangtze River Delta Center for Medical Device Evaluation and Inspection of NMPA， Shanghai 201210， China

Received date: 2025-09-15

Revised date: 2025-10-16

Accepted date: 2026-04-01

Online published: 2026-04-01

Fold

摘要

医用镁基材料因其具有生物可降解性、力学相容性与生物活性，在骨科、心血管等医疗器械领域展现出广阔的应用前景。然而，其在生理环境中降解速率过快、局部产气及pH升高等问题限制了临床转化及应用。本研究系统综述了镁的腐蚀机理及其在不同生理环境（如骨组织、血管、消化系统）中面临的挑战，重点总结了近年来针对在骨科、心血管、胆道等部位应用特点的表面改性技术研究进展，包括化学转化、微弧氧化、聚合物涂层、复合涂层等方法在提升镁基材料耐腐蚀性、生物相容性和功能化（如促骨整合、抗菌、促内皮化）方面的应用。研究表明，通过表面改性可有效调控镁基材料的降解行为，实现降解与组织再生的协调匹配，为其在可降解植入医疗器械中的进一步应用提供理论支持与技术路径。

关键词： ; font-size:medium; ">镁；生物可降解；耐腐蚀；医疗器械；体内外研究

本文引用格式

曲春鸽 , 江珊 , 尤茗语 , 田甜 . 医用镁基材料表面改性技术的研究进展与应用展望[J]. 中国药物评价, 2026 , 43(1) : 9 -9-13 . DOI: 10.2095-3593.2026.030002

Abstract

Magnesium-based materials demonstrate significant potential for applications in orthopedic， cardiovascular， and other medical device fields due to their excellent biodegradability， favorable mechanical compatibility， and bioactivity. However， challenges such as excessively rapid degradation rates， localized gas formation， and elevated pH in physiological environments have hindered their clinical translation. This review systematically examines the corrosion mechanisms of magnesium-based materials and the specific challenges it faces in various physiological milieus (e.g.， bone tissue， blood vessels， and the digestive system). It highlights recent advances in surface modification technologies， including chemical conversion， micro-arc oxidation， polymer coatings， and composite coatings， to enhance the corrosion resistance， biocompatibility， and functional properties (e.g.， osteogenic promotion， antibacterial effects， and endothelialization capability) of these materials. Studies indicate that surface modifications can effectively regulate the degradation behavior of magnesium-based materials， achieving synchronized degradation and tissue regeneration. These findings provide both theoretical support and technical strategies for the further development of degradable magnesium-based implantable medical devices.

Key words： ; font-size:medium; ">Magnesium； Biodegradable； Corrosion resistance； Medical devices； In vitro and in vivo study

参考文献

[1] Atkinson HD， Khan S， Lashgari Y， et al. Hallux valgus correction utilising a modified short scarf osteotomy with a magnesium biodegradable or titanium compression screws-a comparative study of clinical outcomes[J]. BMC Musculosk Disord， 2019， 20：334.
     [2] Bommala VK， Krishna MG， Rao CT. Magnesium matrix composites for biomedical applications： a review[J]. J Magnes Alloys， 2019， 7(1)：72-79.
     [3] Yin ZZ， Qi WC， Zeng RC， et al. Advances in coatings on biodegradable magnesium alloys[J]. J Magnes Alloys， 2020， 8(1)：42-65.
     [4] Prasad SVS， Prasad SB， Verma K， et al. The role and significance of Magnesium in modern day research-a review[J]. J Magnes Alloys， 2022， 10(1)：1-65.
     [5] Curioni M. The behaviour of magnesium during free corrosion and potentiodynamic polarization investigated by real-time hydrogen measurement and optical imaging[J]. Electrochimica Acta， 2014， 120(7)：284-292.
     [6] Staiger MP， Pietak AM， Huadmai J， et al. Magnesium and its alloys as orthopedic biomaterials： a review[J]. Biomaterials， 2006， 27(9)：1728-1734.
     [7] Sankara Narayanan TSN， Park IS， Lee MH. Strategies to improve the corrosion resistance of microarc oxidation (MAO) coated magnesium alloys for degradable implants： prospects and challenges[J]. Prog Mater Sci， 2014， 60：1-71.
     [8] Kannan MB， Raman RKS. In vitro degradation and mechanical integrity of calcium-containing magnesium alloys in modified-simulated body fluid[J]. Biomaterials， 2008， 29(15)：2306-2314.
     [9] Winzer N， Atrens A， Song G， et al. A critical review of the stress corrosion cracking (SCC) of magnesium alloys[J]. Adv Eng Mater， 2005，7(8)：659-693.
     [10] Liu CL， Wang YJ， Zeng RC， et al. In vitro corrosion degradation behaviour of Mg-Ca alloy in the presence of albumin[J]. Corros Sci， 2010， 52(10)：3341-3347.
     [11] Yee DTW， Koon JNC， Huang Y， et al. Bioresorbable metals in cardiovascular stents： material insights and progress[J]. Materialia， 2020， 12：100727.
     [12] Liu L， Liu TE， Cheung TT. A review of biodegradable biliary stents made of magnesium metals： Current progress and future trends[J]. J Magnes Alloys， 2025， 13(1)：30-40.
     [13] Trang LT， Le HV， Hiromoto S， et al. In vitro cellular biocompatibility and in vivo degradation behavior of calcium phosphate-coated ZK60 magnesium alloy[J]. Biomed Mater， 2023， 18(3)：035003.
     [14] Ibrahim H， Billings C， Abdalla M， et al. In vivo assessment of high-strength and corrosion-controlled magnesium-based bone implants[J]. Bioengineering， 2023， 10(7)：877.
     [15] Herzog P， Rendenbach C， Turostowski M， et al. Titanium versus plasma electrolytic oxidation surface-modified magnesium miniplates in a forehead secondary fracture healing model in sheep[J]. Acta Biomater， 2024， 185：98-110.
     [16] Park J， Um SH， Seo Y， et al. Improving hydroxyapatite coating ability on biodegradable metal through laser-induced hydrothermal coating in liquid precursor： Application in orthopedic implants[J]. Bioact Mater， 2023， 25：796-806.
     [17] Byun SH， Lim HK， Lee SM， et al. Biodegradable magnesium alloy (ZK60) with a poly(l-lactic)-acid polymer coating for maxillofacial surgery[J]. Metals， 2020， 10(6)：724.
     [18] Liang J， He Y， Jia R， et al. Enhancing the corrosion resistance of magnesium alloys with biodegradable poly (trimethylene carbonate) chemical modification coating[J]. Mater Today Adv， 2024， 21：100460.
     [19] Govindaraj P， Boopalan R， Orthopaedics， et al. Bilayer nanostructure coated AZ31 magnesium alloy implants： in vivo reconstruction of critical-sized rabbit femoral segmental bone defect[J]. Nanomedicine： Nanotechnology， Biology and Medicine， 2020， 29：102232.
     [20] Ye J， Miao B， Xiong Y， et al. 3D printed porous magnesium metal scaffolds with bioactive coating for bone defect repair： enhancing angiogenesis and osteogenesis[J]. J Nanobiotechnol， 2025， 23(1)：160.
     [21] Wang Q， Liao C， Liu B， et al. Enhanced corrosion resistance， antibacterial properties and osteogenesis by Cu ion optimized Mg Al-layered double hydroxide on Mg alloy[J]. J Magnes Alloys， 2024， 12(10)：4174-4190.
     [22] Gokyer S， Monsef YA， Buyuksungur S， et al. MgCa-based alloys modified with Zn-and Ga-doped CaP coatings lead to controlled degradation and enhanced bone formation in a sheep cranium defect model[J]. ACS Biomater Sci Eng， 2024， 10(7)：4452-4462.
     [23] Shen X， Zhang H， Li X， et al. A hydrophobic layer prepared by cyclic grafting of polydimethylsiloxane on magnesium： improved corrosion resistance and biocompatibility[J]. Regen Biomater， 2022，9： rbac068.
     [24] Li LY， Yang Z， Pan XX， et al. Incorporating copper to biodegradable magnesium alloy vascular stents via a Cu(Ⅱ)-eluting coating for synergistic enhancement in prolonged durability and rapid re-endothelialization[J]. Adv Funct Mater， 2022， 32(47)：2270269.
     [25] Zhang J， Xiang Z， Ren X， et al. Superior toughness anticorrosion-bioactive integrated multilayer coating with excellent adhesion for biodegradable Magnesium-Based stents[J]. Chem Eng J， 2024， 481：148400.
     [26] Pan C， Xu R， Chen J， et al. A CO-releasing coating based on carboxymethyl chitosan-functionalized graphene oxide for improving the anticorrosion and biocompatibility of magnesium alloy stent materials[J]. Int J Biol Macromol， 2024， 271(2)：132487.
     [27] Zan R， Wang H， Shen S， et al. Biomimicking covalent organic frameworks nanocomposite coating for integrated enhanced anticorrosion and antifouling properties of a biodegradable magnesium stent[J]. Acta Biomater， 2024， 180：183-196.
     [28] Ding Z， Yuan Q， Wang H， et al. Microstructure and properties of Nb2O5/Mg gradient coating on AZ31 magnesium alloy by magnetron sputtering[J]. Ceram Int， 2023， 49(1)：154-167.
     [29] Claver A， Iban Quintana I， Fernández I， et al. Duplex treatments prepared by HiPIMS and sol-gel on biodegradable ZK60 magnesium alloy for biomedical applications[J]. Surf Coat Technol， 2025，511：132258.

Options

文章导航

模态框（Modal）标题

摘要

本文引用格式

Abstract

参考文献