Abstract: Objective：To explore the effect of combined treatment of reduced glutathione and entecavir on hepatitis B cirrhosis. Methods： A total of 86 patients with hepatitis B cirrhosis who were admitted to our hospital from July 2017 to July 2019 were selected as the research objects and randomly divided into the control group and the observation group (n=43). The control group was treated with reduced glutathione， the observation group was treated with entecavir on the basis of the control group， and the related indicators of the two groups were compared. Results： After treatment， the levels of inflammatory response indexes were lower than those before treatment， and the observation group was lower than the control group (P＜0.05). The quality of life was improved compared with before treatment， and the observation group was higher than the control group (P<0.05). The adverse reactions between the groups were compared (P＞0.05). Conclusion： Combined treatment of reduced glutathione and entecavir in patients with hepatitis B cirrhosis can effectively improve the body′s inflammatory response， and reduce liver function damage， and improve liver function level and quality of life， which has high safety.

Key words: font-size:medium, ">Reduced glutathione； Entecavir； Hepatitis B cirrhosis； Liver function； Inflammation