CHINESE JOURNAL OF DRUG EVALUATION >

2025 , Vol. 42 >Issue 5: 345 - 345-350

DOI: https://doi.org/magtech-2025-07-11-00003

Study on the Correlation Between the Gene Polymorphisms of CYP2C19， POR and ABCC2 and the Plasma Concentration of Voriconazole in Patients with Invasive Fungal Infections

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  • 1.Kunming Medical University， Yunnan Kunming 650244， China；
    2.Pharmacy Department， Kunming First People′s Hospital， Yunnan Kunming 650244， China

Received date: 2025-07-11

  Revised date: 2025-08-19

  Accepted date: 2025-11-27

  Online published: 2025-12-15

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Abstract

Objective： To investigate the impact of genetic polymorphisms of CYP2C19， POR， and ABCC2 on the trough plasma concentration (cmin) of voriconazole (VRZ) in patients with invasive fungal infection (IFI). Methods： Peripheral blood samples from IFI patients were prospectively collected. The plasma concentration of VRZ was determined using two-dimensional liquid chromatography. Simultaneously， polymerase chain reaction was employed to detect the genetic polymorphisms of CYP219 rs4244285， CYP219 rs4986893， POR rs10954732， and ABCC2 rs717620. The correlation between each genotype and the VRZ plasma concentration was then analyzed. Results： A total of 55 plasma samples of the steady-state trough plasma concentration of voriconazole in IFI patients were enrolled in this study. The analysis revealed that at the CYP2C19 rs4244285 locus， the VRZ cmin value in patients with the GG genotype was significantly lower than that in A allele carriers (P<0.05). Similarly， at the CYP2C19 rs4986893 locus， the VRZ cmin value in patients with the GG genotype was markedly lower than that in A allele carriers (P<0.05). At the ABCC2 rs717620 locus， the VRZ cmin value in patients with the CC genotype was significantly lower than that in T allele carriers (P<0.05). However， no significant correlation was observed between the POR rs10954732 locus and the VRZ cmin value in IFI patients (P>0.05). There were significant differences in VRZ cmin among IFI patients with different CYP2C19 metabolic distributions (P<0.01). After stratification based on CYP2C19 metabolic distribution， the influence of the genetic polymorphisms of POR rs10954732 and ABCC2 rs717620 on VRZ cmin in IFI patients did not reach statistical significance. Conclusions： Carriers of the T allele of ABCC2 rs717620 can increase the plasma concentration of VRZ. In the metabolic distribution of CYP2C19， the minimum steady-state concentration of VRZ in PMs patients is higher than that in EMs and IMs patients. After classifying the metabolic distribution of CYP2C19， the gene polymorphisms of POR rs10954732 and ABCC2 rs717620 have no effect on the VRZ cmin in patients with invasive fungal infection.

Key words： ; font-size:medium; ">Voriconazole； Invasive fungal infection； CYP2C19； POR； ABCC2； Genetic polymorphism； Plasma concentration

Cite this article

LI Yaxuan, LI Xingde, WANG Guohui, MAO Panpan, ZHANG Hanshu, LU Saijuan, SONG Cangsang . Study on the Correlation Between the Gene Polymorphisms of CYP2C19， POR and ABCC2 and the Plasma Concentration of Voriconazole in Patients with Invasive Fungal Infections[J]. CHINESE JOURNAL OF DRUG EVALUATION, 2025 , 42(5) : 345 -345-350 . DOI: magtech-2025-07-11-00003

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