CHINESE JOURNAL OF DRUG EVALUATION >

2025 , Vol. 42 >Issue 6: 482 - 482-486

DOI: https://doi.org/10.2095-3593.2025.120005

Effect of Yuanhu Zhitong Dropping Pill Combined with Yangxue Qingnao Granules on Migraine Patients

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  • 988 Hospital of the Joint Service Support Force of the Chinese People′s Liberation Army，Henan Zhengzhou 450000， China

Received date: 2025-01-15

  Revised date: 2025-05-12

  Accepted date: 2026-01-07

  Online published: 2026-01-07

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Abstract

Objective： To investigate the effect of Yuanhu Zhitong Dropping Pill combined with Yangxue Qingnao Granules in migraine patients. Methods： A total of 102 migraine patients treated in our hospital from June 2023 to April 2024 were randomly divided into a control group (n=52) and an observation group (n=50) based on different treatment protocols. The control group received Yangxue Qingnao Granules， whereas the observation group received a combination of Yuanhu Zhitong Dropping Pill and Yangxue Qingnao Granules. The clinical efficacy and incidence of adverse reactions were compared between the two groups， as well as the levels of cerebral hemodynamics [posterior cerebral artery (PCA)， middle cerebral artery (MCA)， anterior cerebral artery (ACA)]， vascular endothelial function [5-hydroxytryptamine (5-HT)， endothelin (ET)， nitric oxide (NO)]， and serum inflammatory factors [high-sensitivity C-Reactive protein (hs-CRP)， intercellular adhesion molecule-1 (ICAM-1)， tumor necrosis factor (TNF)-α， calcitonin gene-related peptide (CGRP)] before and after treatment. Results： The total clinical effective rate of the observation group was 90.00%， which was higher than that of the control group (75.00%) (P<0.05)； the levels of PCA， MCA， and ACA in the observation group were lower than those in the control group after treatment (P<0.05). The levels of 5-HT， ET， and NO in the observation group were lower than those in the control group after treatment (P<0.05)； the decrease in the levels of hs-CRP， CGRP， TNF-α， and ICAM-1 in the observation group after treatment was greater than that in the control group (P<0.05)； the incidence of adverse reactions in the observation group was 12.00%， which was not significantly different from the control group′s 9.62% (P>0.05). Conclusion： The combination of Yuanhu Zhitong Dropping Pill and Yangxue Qingnao Granules has a significant effect in treating migraine， which can not only regulate cerebral hemodynamics， improve vascular endothelial function， but also inhibit inflammatory reaction in vivo， and has certain safety.

Key words： ; font-size:medium; ">Yuanhu Zhitong Dropping Pill； Yangxue Qingnao Granules； Migraine； Cerebral hemodynamics

Cite this article

LV Mengmeng, ZHANG Zhenhong, ZHANG Jinyan, NIU Wenshu . Effect of Yuanhu Zhitong Dropping Pill Combined with Yangxue Qingnao Granules on Migraine Patients[J]. CHINESE JOURNAL OF DRUG EVALUATION, 2025 , 42(6) : 482 -482-486 . DOI: 10.2095-3593.2025.120005

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