CHINESE JOURNAL OF DRUG EVALUATION >

2026 , Vol. 43 >Issue 1: 50 - 50-55

DOI: https://doi.org/10.2095-3593.2026.030006

Research Progress on the Chemical Composition， Pharmacological Effects and Toxicology of Acorus tatarinowii Schott

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  • Center for Information， National Medical Products Administration， Beijing 100163， China

Received date: 2025-12-22

  Revised date: 2025-12-29

  Accepted date: 2026-04-01

  Online published: 2026-04-01

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Abstract

Acorus tatarinowii Schott， as a traditional Chinese medicinal material， has a long history of medical use. In recent years， significant progress has been made in the research on its chemical composition， pharmacological effects， and toxicology. This paper systematically reviews the chemical composition， multi-target pharmacological mechanisms， and current status of toxicological research on Acorus tatarinowii Schott， aiming to provide a scientific basis for its clinical rational application and quality standardization. Chemical composition analysis shows that the main active component of Acorus tatarinowii Schott is volatile oil， with the highest content of β-asarone， and it also contains various active substances such as flavonoids， alkaloids， and polysaccharides. Pharmacological research shows that Acorus tatarinowii Schott has significant neuroprotective effects and can improve cognitive function by regulating neurotransmitters， antioxidant， anti-inflammatory， and inhibiting cell apoptosis. Its cardiovascular protective effects involve inhibiting inflammatory responses， promoting angiogenesis， and improving energy metabolism. In addition， Acorus tatarinowii Schott also has multiple pharmacological activities such as antimicrobial， antioxidant， anticancer， and immunomodulatory effects. Toxicological studies have shown that Acorus tatarinowii Schott has high safety in short-term use， but its main active component， β-asarone， has a certain dose-dependent toxicity， and further systematic assessment is needed to identify potential risks. Future research should focus on standardizing the composition， elucidating the material basis of pharmacological effects of Acorus tatarinowii Schott， and promoting the clinical translation， thereby advancing its rational application and development in the fields of nervous system and cardiovascular diseases.

Key words： ; font-size:medium; ">Acorus tatarinowii Schott； Volatile oil； Chemical composition； Pharmacological effects； Toxicology； Molecular mechanism

Cite this article

WEN Qinghui, GUO Shujin . Research Progress on the Chemical Composition， Pharmacological Effects and Toxicology of Acorus tatarinowii Schott[J]. CHINESE JOURNAL OF DRUG EVALUATION, 2026 , 43(1) : 50 -50-55 . DOI: 10.2095-3593.2026.030006

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