Abstract: Objective：A GC-MS method was established for the determination of 21phthalate plasticizers in Ligustrazine Phosphate and Sodium Chloride Injection. Methods：The determin ation was performed on DB-5MS column at the flow rate of 1.0 mL·min-1 using helium as carrier gas， injector temperature was 260 ℃ by temperature programming. Electron impact（EI）ionization mode was used， MRM was used for quantity analysis， the assays of phthalates elasticizers in 3 batches Ligustrazine Phosphate and Sodium Chloride Injection were determined. Results： 21 kinds of phthalates could be completely separated under the condition of GC-MS. The linear ranges were 80~2 000 ng·mL-1. The limit of detection was more than 2 ng·mL-1 and average recoveries were 90.7%~97.1%. Conclusion：This work provided an effective， accurate， sensitive and simple method for the rapid detection of huge quantity of samples.

Key words: font-size:medium, ">GC-MS；Phthalate plasticizers；Ligustrazine Phosphate and Sodium Chloride Injection