Abstract: Objective：To disscuss the clinical characteristics,regular and reasons of adverse drug reaction in Harbin. To provide references for rational use of clinical drug. Methods：1132 cases of adverse drug reaction reported were analyzed retrospectively from January 1,2011 to March 31, 2011. Results：In 1132 cases of adverse drug reactions, most of the patients with adverse drug reaction were 60 years of age or older, accounted for 22.18%. The intravenous route of administration was the major cause of adverse drug reaction , accounting for 64.40%. Skin and its appendages damage was the major clinical manifestations, accounting for 47.35%. Most adverse drug reactions caused by anti-infectives, accounting for 61.31%. Conclusion：Strengthen rational use of drugs to reduce the occurrence of adverse drug reaction .