Abstract: The method of drug valid for automation management is designed to promote the pharmaceutical scientific and standardized management and to prevent the unsafe use of expired drugs. Real-time associate of the basis of data and computer system time by the calendar notepad software displays the alert results. The recent period of limitation drug on the expected requirements is automatically reminded. The method is simple and easy to learn, easy to adapt, greatly improved work efficiency and quality. It applies to hospital pharmacy without network management. It effectively curbs the shelves, inventory, sales, use of expired drugs, and effectively provides a strong guarantee for the clinical drug safety.