阿德福韦治疗E抗原阳性慢性乙肝的疗效及其影响因素

• 药品评价-循证医学研究 • 上一篇下一篇

阿德福韦治疗E抗原阳性慢性乙肝的疗效及其影响因素

宋茂舟,陈燕,袁锐坤,范俊杰,叶志明

广东省东莞市常平医院感染科,广东省东莞市常平医院感染科,广东省东莞市常平医院感染科,广东省东莞市常平医院感染科,广东省东莞市常平医院感染科

收稿日期:2013-03-08 修回日期:2013-04-15 出版日期:2013-04-25 发布日期:2013-04-25

Efficacy of Adefovir dipivoxil for patients with HBeAg positive chronic hepatitis B and its influencing factor

songmaozhou,chengyan,yuanruikun,fanjunjie and yezhiming

Chang Ping Hosipitol of Dongguan,Chang Ping Hosipitol of Dongguan,Chang Ping Hosipitol of Dongguan,Chang Ping Hosipitol of Dongguan,Chang Ping Hosipitol of Dongguan

Received:2013-03-08 Revised:2013-04-15 Online:2013-04-25 Published:2013-04-25

摘要/Abstract

摘要： 【】目的　观察国产阿德福韦(ADV)治疗HBeAg阳性慢性乙肝的临床疗效并分析影响疗效的相关因素。方法　收集2005年6月至2011年9月在我院采用国产ADV治疗的118例HBeAg阳性慢性乙型肝炎患者临床资料,观察48周时的疗效,分析治疗前ALT水平、HBVDNA水平、体重指数(BMI)及年龄等因素与疗效的相关性。结果　ADV治疗48周时,ALT复常率为88％; HBVDNA转阴率为43.22％;22.03％患者E抗原消失,其中18.64％患者发生E抗体血清学转换；耐药率为0％。获得HBVDNA转阴者较未获得转阴患者基线ALT水平较高、HBVDNA载量较低、年龄较轻、BMI较小、24周获得初始病毒学应答(IVR)比例更高。结论　国产ADV可以有效地抑制HBVDNA复制、改善肝功能,促进HBeAg血清学转换。血清HBVDNA水平较低、ALT水平较高、BMI较低及年龄较轻的患者更易对ADV标准治疗方案产生疗效。

Abstract: 【Objective】 To observe the efficacy of domestic adefovir dipivoxil(ADV) in the treatment of patients with HBeAg positive chronic hepatitis B and analyse influencing related factors of the curative effect. 【Methods 】118 patients with HBeAg positive chronic hepatitis B were collected from 2005 June to 2011 September in our hospital .They were treated with domestic ADV for 48 weeks.The clinical data was collected. The efficacy was observed and the relevance of therapeutic and factors such as ALT level,HBVDNA level, body mass index ( BMI ) and age before treatment were analysed. 【Results 】After 48 weeks,ALT recovery rate was 88%;HBVDNA negative rate was 43.22%;22.03% patients’E antigen lost, 18.64% of them occurred E antibody serological conversion;and the resistant rate was 0%.The patients with HBVDNA negative conversion had the higher baseline ALT levels , the lower HBVDNA load, the smaller BMI, the higher percentage of obtaining Initial virologic response ( IVR ) at 24 weeks ,and they were younger . 【Conclution 】Domestic ADV can effectively inhibit HBVDNA replication,improve liver function,promote HBeAg serological conversion.The patients with the lower level of serum HBVDNA, the higher ALT levels,the lower BMI and the younger produce

宋茂舟,陈燕,袁锐坤,范俊杰,叶志明. 阿德福韦治疗E抗原阳性慢性乙肝的疗效及其影响因素[J]. .

songmaozhou,chengyan,yuanruikun,fanjunjie and yezhiming. Efficacy of Adefovir dipivoxil for patients with HBeAg positive chronic hepatitis B and its influencing factor[J]. .