中药金莲花药效组分抗炎镇痛作用研究

中药金莲花药效组分抗炎镇痛作用研究

杨静伟,张贵君,吴明侠,杨晶凡

黑龙江省药品审评认证中心;北京中医药大学;河南中医学院;河南中医学院

收稿日期:2013-05-20 修回日期:2013-06-25 出版日期:2013-08-25 发布日期:2013-08-25
基金资助:
广东省教育部产学研项目（项目编号：2007B090400085）;河南中医学院博士科研基金项目（项目编号：BSJJ2009-10）

Anti-inflammatory analgesic pharmacological effects of Flos Trollii Chinensis and its active components alignment

杨静伟 and 杨晶凡

Heilongjiang Center for Drug Evaluation and Certification

Received:2013-05-20 Revised:2013-06-25 Online:2013-08-25 Published:2013-08-25

摘要/Abstract

摘要： 目的研究金莲花药效组分及金莲花水煎液的抗炎镇痛作用。方法通过抗炎、镇痛药理实验观察金莲花水煎液及其药效组分的药理活性。结果通过金莲花水煎剂组与其药效组分高、中、低剂量组比较,金莲花水煎剂及其药效组分中、高剂量组与模型组比较均有显著性差异(P<0.05),说明均具有抗炎和镇痛作用。金莲花水煎剂组与金莲花药效组分中剂量组间无显著性差异(P＞0.05)。金莲花水煎剂及其药效组分均不能缓解热板致小鼠疼痛,与模型组比较无显著性差异(P＞0.05),说明其不具有中枢镇痛作用。结论金莲花水煎液具有抗炎镇痛药理作用,用于治疗咽炎和上呼吸道感染是有药理依据的。金莲花药效组分与金莲花水煎液药理作用无显著性差异,金莲花药效组分一定程度上可以反映金莲花的抗炎镇痛药理作用。

Abstract: Objetive: To investigate the in vivo anti-inflammatory of the water extract from Flos Trollii Chinensis and its active components alignment. Methods: A group of anti-inflammatory and analgesic pharmacological experiments were employed to observe the antagonistic effect. Results: Both Flos Trollii Chinensis group and active compounds alignment group have effect on anti-inflammatory pharmaco-experiment and relieving pain experiment(P<0.05). There are no marked difference between Flos Trollii Chinensis group and active compounds alignment group(P＞0.05). Conclusion: The water extract frome Flos Trollii Chinensis have anti-inflammatory and analgesic effect which is related to clinical application. The active compounds alignment of Flos Trollii Chinensis can reflect the efficacy of Flos Trollii Chinensis to a certain degree.

杨静伟,张贵君,吴明侠,杨晶凡. 中药金莲花药效组分抗炎镇痛作用研究[J]. .

杨静伟 and 杨晶凡. Anti-inflammatory analgesic pharmacological effects of Flos Trollii Chinensis and its active components alignment[J]. .