• 中国核心期刊(遴选)数据库收录期刊
  • 中文科技期刊数据库收录期刊
  • 中国期刊全文数据库收录期刊
  • 中国学术期刊综合评价数据库统计源期刊等

• 药品评价-循证医学研究 • 上一篇    下一篇

二甲双胍对糖尿病患者黎明现象的治疗效果观察

李芝   

  1. 广东省佛山市顺德区桂洲医院内四科 528304
  • 收稿日期:2013-07-17 修回日期:2013-07-17 出版日期:2013-08-25 发布日期:2013-08-25

Effect of metformin hydrochloride on dawn phenomenom in diabetes

  1. GueiZhou hospital, shunde, Foshan city, Guangdong
  • Received:2013-07-17 Revised:2013-07-17 Online:2013-08-25 Published:2013-08-25

摘要: 目的:使用动态血糖监测系统观察二甲双胍治疗黎明现象的效果。方法:选取经佩带动态血糖监测系统(CGMS )后确诊为黎明现象的2型糖尿病患者56例,给予睡前口服盐酸二甲双胍0.5-0.85g,对比治疗前后患者血糖变化,观察黎明现象改善情况。结果:经二甲双胍治疗后,黎明现象得到明显改善,空腹血糖达标率为85.7%,全天血糖均值、日内平均血糖波动幅度、血糖≥8.0mmol/L所占时间百分比均较治疗前下降,差异有统计学意义(P <0.05),血糖≤3.9mmol/L时间比差异无统计学意义(P>0.05)。结论:盐酸二甲双胍可以有效安全的改善大部分糖尿病患者的黎明现象。

Abstract: Objective To observe early moming hyperglycaemia “dawn phenomenom” in type 2 diabetes mellitus with continuous glucose monitoring system and assessment of curative effect by Metformin Hydrochloride. Methods fifty-six type 2 diabetes patients with dawn phenomenom was measured by continuous glucose monitoring system before Metformins Hydrochloride were taken,assessment of curative effect before and after Metformin therapy. Results The dawn phenomenom were observed in patients by CGMS. Metformin Hydrochloride,0.5-0.85g,QN were given and the dawn phenomenon were improved significantly. The attainment rate of the blood glucose were 85.7%.verage glycemic values、The mean amplitude of glycemic fluctuation、The percentage of TBG ≥8.0 mmol/L were reduced,there were significant diferences(P<0.05).The percentage of TBG≤ 3.9mmol/L were no significant diferences after treatmate(P>O.05).Conclusions Metformin Hydrochloride can effectively improve the “dawn phenomenom”in some type 2 diabetes patients.