• 中国核心期刊(遴选)数据库收录期刊
  • 中文科技期刊数据库收录期刊
  • 中国期刊全文数据库收录期刊
  • 中国学术期刊综合评价数据库统计源期刊等

• 药物研究 • 上一篇    下一篇

阿立哌唑与氯氮平治疗精神分裂症阳性症状 对照研究的Meta分析

李金龙,马继春,张盼,王婧,丁界先,田金徽   

  1. 兰州大学第一临床医学院,兰州大学循证医学中心,,,,,兰州大学循证医学中心
  • 收稿日期:2013-11-06 修回日期:2013-11-06 出版日期:2013-12-25 发布日期:2013-12-25

Meta-analysis of Aripiprazole Versus Clozapine in the Treatment of Positive Symptoms of Schizophrenia

  1. 1. School of basic medical science,evidence-based medicine center,Lanzhou university,1. School of basic medical science,evidence-based medicine center,Lanzhou university,1. School of basic medical science,evidence-based medicine center,Lanzhou university,
  • Received:2013-11-06 Revised:2013-11-06 Online:2013-12-25 Published:2013-12-25

摘要: 目的:探讨阿立哌唑与氯氮平治疗精神分裂症阳性症状疗效的差异。方法:计算机检索CENTRAL、PubMed、EMBASE、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)等,检索时间从各数据库建库至2013年9月20日,同时辅助其它检索。应用Meta分析方法对纳入的44项阿立哌唑与氯氮平治疗精神分裂症的随机对照研究进行再分析,重新评价其疗效和生活质量。结果:①阿立哌唑治疗精神分裂症阳性症状前后的自身对照,差异有统计学意义[MD=-12.46, 95%CI (-12.46,-11.43), P<0.00001]。②阿立哌唑与氯氮平在改善精神分裂症患者阳性症状的组间比较,差异无统计学意义[MD=0.30, 95%CI (-0.35,0.94), P=0.37]。③阿立哌唑与氯氮平治疗精神分裂症的有效率无统计学差异[OR=0.96, 95%CI (0.76, 1.20), P=0.70]。④在改善生活质量方面,阿立哌唑组优于氯氮平组,且差异具有统计学意义[MD=2.60, 95%CI(2.24,2.96) P<0.00001]。结论:阿立哌唑与氯氮平在治疗精神分裂症阳性症状的疗效无统计学差异,但阿立哌唑能更好地改善患者生活质量。

Abstract: Objective: To study the difference of efficacy between aripiprazole and clozapine in the treatment of schizophrenia with positive symptoms. Methods:We systematically searched CENTRAL, PubMed, EMBASE, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), VIP Database from inception through September 20, 2013. 44 studies that compared effects difference in treatment of positive symptoms between aripiprazole and clozapine were analyzed by meta-analysis to re-evaluate the therapeutic effects of the two drugs. Results: ①Pre-treatment and post-treatment for aripiprazole was compared, the result showed that aripiprazole has good effect on positive symptoms [MD=-12.46, 95%CI (-12.46, -11.43), P<0.00001]. ②Compared post-treatment between aripiprazol and clozapine for positive symptoms of schizophrenia, the difference was statistically insignificant [MD=0.30, 95%CI (-0.35,0.94), P=0.37]. ③The efficiency was similar for aripiprazole and clozapine, there is no statistically significant [OR=0.96, 95%CI (0.76, 1.20), P=0.70]. ④ Aripiprazole can statistically significant improve the quality of life [MD=2.60, 95%CI (2.24,2.96), P<0.00001]. Conclusion: Aripiprazole and clozapine was no significant difference in the treatment of positive symptoms of schizophrenia, however, aripiprazole was better for quality of life.