Abstract: Objective To establish a head-space GC method for determination of residual solvents in Faropenem Sodium. Methods The gas chromatograph is equipped with a flame-ionization detector and TG-624 capillary column. The carrier gas is nitrogen with about 5ml per minute. The column temperatures is maintained at 50℃ for 3 minutes ,then raised at a rate of 10℃ per minute to 200℃,and maintained at 200℃ for 2minutes.The injection port and detector temperatures are maintained at 200℃ and 250℃, respectively. Headspace equilibration temperature is 110℃ an equilibration time is 30 minutes. Results A good linearity was obtained with in the designed range of each solvent. The average recoveries were from 88%-107%. The RSD of precision and accuracy test were1.85%、1.33%、1.11%、0.76%、3.6%、1.55%, respectively, they all meet the correlative criterion of Ch.p Conclusion The method was proved to be simple and accurate. It has a good reproducibility and can be used to determinate the six residual solvents in Faropenem Sodium.