Abstract: Objective: By developing the evaluation methods and the conversion from SCT to AET of the extractable and leachable in the compatibility, the toxicological data can be converted to analysis data of chemicals, so we can control the leachables in compatibility studies. Methods: literature review, and the summary of several important concepts and key threshold identified by the toxicologists and chemists from PQRI, and make examples. Meaning: to provide clear ideas and methods for the research and control of extractables and leachables in the process of drug development and production.