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• 药品评价-循证医学研究 •    下一篇

格列美脲和格列本脲治疗2型糖尿病有效性和安全性的mete分析

杨婷婷,马爱霞   

  1. 中国药科大学国际医药商学院,中国药科大学国际医药商学院
  • 收稿日期:2014-02-11 修回日期:2014-02-11 出版日期:2014-04-25 发布日期:2014-04-25

A Meta-analysis of Efficacy and Security of Glimepiride and Glyburide in patients with T2DM

杨婷婷 and   

  1. China Pharmaceutical University School of International Pharmaceutical Business,
  • Received:2014-02-11 Revised:2014-02-11 Online:2014-04-25 Published:2014-04-25

摘要: 目的:比较格列美脲和格列本脲的有效性和安全性。方法:通过检索国内外1995-2013年发表的关于格列美脲和格列本脲治疗2型糖尿病的中英文文献,并以Jadad评分标准结合Cochrance简单评价方法评价纳入文献的研究质量,对纳入的文献使用Review Manager 5.0进行meta分析。结果:共检索文献45篇,按照纳入和排除标准,最终筛选12篇进行meta分析。Meta分析结果:有效性meta分析,格列美脲在HbA1c、FBG、2hPBG方面与格列本脲差异无统计意义(p>0.05);安全性meta分析,格列美脲与格列本脲在低血糖发生率方面有显著差异,(P<0.05)格列美脲低血糖发生率显著低于格列本脲组。结论:格列美脲与格列本脲治疗2型糖尿病疗效相当,但格列美脲低血糖发生率低于格列本脲,更安全。

Abstract: Objective: compare the efficacy and security of Glimepiride and Glyburide . Methods: Inputs for the meta-analysis were chosen from the literature published both in the domestic and overseas during 1995 to 2013 about Glimepiride and Glyburide in the treatment of T2DM by using Jadad grading standard and Cochrance review. Review Manager 5.0 was used to conduct the meta-analysis of chosen literature. Results: twenty-two literature(8in Chinese, 4 in English) were chosen from all the 45 retrieved papers according to exclude and inclusive criterias.