Abstract: Objective To analyze the use of oral hypoglycemic agents by outpatient in the hospital during 2010-2012, so as to provide preference for clinical rational drug use. Methods The information of various types of oral hypoglycemic by outpatient during 2010-2012 from the HIS system was obtained, the using frequency and cost per day were statistically analyzed and compared. Results Acarbose of sales amount for three consecutive years first row; Metformin of use frequency increased year by year, 2 years in first row, and the cost per day minimum; The serial number ratio greater than 1 is metformin. Conclusion The use of oral hypoglycemic agent in the hospital is reasonable, Metformin of use frequency is high, conform to the principle of safe, effective and economic medication.