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• 药品评价-安全性研究 • 上一篇    下一篇

我院254例药品不良反应/事件调查分析

桂月,华国栋   

  1. 北京中医药大学东方医院,北京中医药大学东方医院
  • 收稿日期:2014-07-07 修回日期:2014-07-09 出版日期:2014-08-25 发布日期:2014-08-25

Investigation and Analysis of 254 ADR/ADE Cases in our Hospital

桂月 and 华国栋   

  1. Dongfang Hospital Beijing University of Chinese Medicine,Dongfang Hospital Beijing University of Chinese Medicine
  • Received:2014-07-07 Revised:2014-07-09 Online:2014-08-25 Published:2014-08-25

摘要: 目的:了解我院药品不良反应/事件(adverse drug reaction/Events,ADR/ADE)发生规律及特点,促进临床合理用药。方法:收集我院2013年上报的254例ADR/ADE报告,按照患者的年龄、药品种类、给药途径、药品不良反应累及系统-器官及临床表现、合并用药情况进行分类统计与分析。结果:254例ADR/ADE报告中以抗微生物药物的发生例次为首位,占37.66%;中药注射剂次之,占15.82%。静脉滴注是引发ADR/ADE的主要给药途径,占68.99%;ADR/ADE累及的主要系统-器官为皮肤系统,临床表现主要以皮疹、瘙痒为主。结论:应加强ADR相关知识的培训,提高临床医务人员对ADR/ADE监测工作的认识,增强上报意识,减少药品不良反应的发生,确保患者的用药安全。

Abstract: Objective:To study the regularity and the features of adverse drug reaction /Events (ADR/ADE) occurred in our hospital, to promote rational drug use in the clinic. Methods:The reports on 254 cases of ADR/ADE collected in our hospital in 2013,were classificated and analyzed according to the age of patients, drug types, routes of administration, organs or systems involved in drug adverse reaction , clinical manifestations and combined drugs. Results:In 254 cases, 37.66% were induced by antimicrobial drugs dominated the first place and 15.82% by the Traditional Chinese Medicine Injections as the second place. Most cases were resulted from intravenous infusion which accounted for 68.99%of the total, skin and its accessories damage accounted for the highest percentage of ADR/ADE. Conclusion:To strengthen the ADR related knowledge training, improve the ability of clinical staff during ADR/ADE monitoring work and enhance the reporting awareness in order to reduce the incidence of ADR/ADE and ensure the medication safety of patients.