Abstract: ABSTRACT: Objective To observe the clinical safety and effect of anaesthetic drugs propofol combined with dexmedetomidine in single-balloon enteroscopy examination. Methods 60 patients,scheduled for single-balloon enteroscopy examination were randomly divided into propofol group(Group A) and propofol combined with dexmedetomidine group (Group B)，n=30 each. The blood pressure(MAP), respiratory rate(RR),heart rate(HR),blood oxygen saturation(SPO2),induction time,recovery time,total propofol dosage of two groups were observed during the examination. Adverse reactions such as body movements , bradycardia,apnea/respiratory depression,awareness of intraoperative and nausea,vomitting,satisfaction of postoperative were recorded. Results All patients had completed the examination successfully.MAP of group A and HR of group B were decreased significantly after anesthesia induction (P<0. 05). There had no statistical significance in the perioperative RR, SPO2 , induction time,recovery time and satisfaction of two groups (P>0.05) . Total propofol dosage of group B were significantly less than group A and Ramsay score of group B were better than group A.Adverse reactions such as body movements , apnea/respiratory depression of group B were significantly less than group A,but bradycardia rate increased(P<0. 05). Conclusion Propofol combined with dexmedetomidine which save the total propofol dosage and reduce the adverse reaction can provide a safe and effective means in single-balloon enteroscopy examination.