细菌溶解产物防治小儿反复呼吸道感染的Meta分析

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细菌溶解产物防治小儿反复呼吸道感染的Meta分析

马骏捷,刘国恩,姚瑶,徐菲,吕娜

北京大学中国卫生经济研究中心,北京大学中国卫生经济研究中心,北京大学中国卫生经济研究中心,北京大学中国卫生经济研究中心,优时比制药有限公司

收稿日期:2014-08-25 修回日期:2014-08-25 出版日期:2014-10-25 发布日期:2014-10-25

The Effect of Bacterial Lysates on Patients with Recurrent Respiratory Tract Infections: A Meta-Analysis

PKU China Center for Health Economics Research,,,,

Received:2014-08-25 Revised:2014-08-25 Online:2014-10-25 Published:2014-10-25

摘要/Abstract

摘要： 目的：对细菌溶解产物防治RRTI患者急性呼吸道感染的效果进行荟萃分析。方法:对象为接受免疫刺激剂治疗的RRTI患者,效果指标为通过荟萃分析得到的患者RRTI发作次数,检索时间范围为2000年1月1日到2013年11月10日。结果：共检索到128篇文献,其中19项研究满足本研究的纳入标准,共959名患者。荟萃分析显示,在常规治疗的基础上加用细菌溶解产物制剂,能显著的减少RRTI患者急性呼吸道感染的发作次数,敏感性分析显示结果稳健。与单用常规治疗的患者相比,12个月内,加用细菌溶解产物的患者平均减少了2.963次急性呼吸道感染。结论：对RRTI患者,在治疗中使用细菌溶解产物能改善患者健康,降低患者发病风险。

Abstract: Objectives: The use of bacterial lysates as an immune-modulator to boost immunological response in patients with Recurrent Respiratory Tract Infections and its effects on the attack frequency of respiratory infection have been widely debated. We aimed to conduct our meta-analysis on the effect of bacterial lysates plus routine care versus routine care only on the attack frequency of respiratory infection in patients with Recurrent Respiratory Tract Infections. Methods: We performed a systematic review of articles published from Jan 1, 2000 to Nov 10, 2013. We included all randomized trials that compared outcomes between patients with Recurrent Respiratory Tract Infections receiving bacterial lysates plus routine care with those receiving routine care only. Eligible studies, determined by consensus with predefined criteria, were reviewed and data were extracted onto a standard form. We combined data to assess the primary outcome of attack frequency of respiratory infection using the DerSimonian and Laird random effects model. RESULTS: Our search identified 128 reports, of which twelve studies met our inclusion criteria and were included in our meta-analysis. Analysis of the 12 randomized trials (959 patients) that reported an outcome on the attack frequency of respiratory infection showed that patients assigned to bacterial lysates plus routine care had a 2.963 reduction in respiratory tract infections compared to those assigned to routine care only. Conclusions: Bacterial lysates are associated with a decreased risk of respiratory tract infections in patients with Recurrent Respiratory Tract Infections.

马骏捷,刘国恩,姚瑶,徐菲,吕娜. 细菌溶解产物防治小儿反复呼吸道感染的Meta分析[J]. .

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