喹硫平对甲状腺功能改变与糖脂代谢的相关性分析

喹硫平对甲状腺功能改变与糖脂代谢的相关性分析

张格艳,王雁芬,孙平平,宋环霞,霍军,孔德荣

郑州市第八人民医院河南郑州 450006,郑州市第八人民医院河南郑州 450006,郑州市第八人民医院河南郑州 450006,郑州市第八人民医院河南郑州 450006,郑州市第八人民医院河南郑州 450006,郑州市第八人民医院河南郑州 450006

收稿日期:2014-10-29 修回日期:2014-10-29 出版日期:2014-12-25 发布日期:2014-12-25
基金资助:
常州四药临床药学科研基金 (CZSYJJ12018)

Correlation Analysis of Quetiapine Caused Changes on Serumthyroxine and Glucolipid Metabolism of Schizophrenia Patients

The eighth people hospital of Zhengzhou,The eighth people hospital of Zhengzhou,The eighth people hospital of Zhengzhou,The eighth people hospital of Zhengzhou,The eighth people hospital of Zhengzhou,The eighth people hospital of Zhengzhou

Received:2014-10-29 Revised:2014-10-29 Online:2014-12-25 Published:2014-12-25

摘要/Abstract

摘要： 目的：探讨喹硫平对精神分裂症患者甲状腺激素及血糖、血脂水平的影响。方法：对30例精神分裂症患者口服喹硫平治疗，观察12周。治疗前后分别测定血清三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺素（TSH）、空腹血糖（GLU）、胆固醇（TC）和甘油三酯（TG）水平的变化，并对各因素水平变化进行相关性分析。结果：与治疗前比较，血清T3和FT3水平分别有显著降低 (P＜0.01、P＜0.05)。T4、FT4水平显著降低(P＜0.05)。TSH变化无统计学差异。TC、TG和 GLU水平显著升高(P＜0.05、P＜0.01、P＜0.05)；T3变化与TG变化呈显著负相关(P＜0.05)。FT3变化与TC变化呈正相关（P＜0.05)，其他因素间均无相关性。结论：喹硫平能降低精神分裂症患者甲状腺激素水平，升高血糖、血脂水平，且甲状腺激素水平与血脂代谢有一定的相关性。

Abstract: Objective：To explore the influences of quetiapine on thyroxine， blood glucose，lipid levels of schizophrenia patients. Methods： 30 schizophrenia patients took orally quetiapine for 12 weeks.Changes of thyroxine， blood glucose，lipid levels were detected before and after treatment， and analyze correlations of between factor changes. Results： T3 and FT3 were significantly decreased than before treatment (P＜0.01, P＜0.05). T4 and FT4 was significantly decreased (P＜0.05).There was no significant difference in serum TSH compared with pre-treatment.TC, TG and GLU were significantly increased (P<0.05, P<0.01, P<0.05). Changes between T3 and TG were negatively correlated (P<0.05).Changes between FT3 and TC were positively correlated(P<0.05). Other facters had no correlation. Conclusion： Quetiapine could reduce thyroid， and elevated blood glucose，lipid levels of schizophrenia patients. Thyroid hormone levels had a certain correlation with blood lipid metabolism.

张格艳,王雁芬,孙平平,宋环霞,霍军,孔德荣. 喹硫平对甲状腺功能改变与糖脂代谢的相关性分析[J]. .