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兰索拉唑联合中药治疗湿热中蕴型急性胃黏膜病变的临床研究

曹志群,高军,李晓宇,张晓彤,丁振,孙蓉   

  1. 山东中医药大学附属医院,山东中医药大学,山东省中医药研究院,山东中医药大学,山东中医药大学,山东省中医药研究院
  • 收稿日期:2014-12-04 修回日期:2014-12-04 出版日期:2014-12-25 发布日期:2014-12-25
  • 基金资助:
    国家重大新药创制科技重大专项课题:中药复方药理学研究及药效学评价关键技术(2009ZX09502-015);山东省中医药科学技术研究项目:内镜下胃粘膜疾病的辨证规律研究(2009097)

Clinical Study on Lansoprazole Combined with Traditional Chinese Medicine in the Treatment of Damp-heat Stasis in the Middle-jiao Acute Gastric Mucosal Lesion

  1. AffiliatedSHospitalSofSShandongSUniversitySofSTraditionalSChineseSMedicine,Shandong?University?of?Traditional?Chinese?Medicine,Shandong?Academy?of?Chinese?Medicine,Shandong?University?of?Traditional?Chinese?Medicine,,
  • Received:2014-12-04 Revised:2014-12-04 Online:2014-12-25 Published:2014-12-25

摘要: 目的:探讨兰索拉唑联合中药治疗湿热中蕴型急性胃黏膜病变的临床疗效。方法:将临床诊断为湿热中蕴型急性胃黏膜膜病变90例患者,随机分为兰索拉唑对照组、中药对照组和兰索拉唑联合中药治疗组(以下简称联合用药组),每组30例患者,对比观察分析疗效差异。结果:联合用药组总有效率为96.7%,兰索拉唑对照组和中药对照组总有效率分别为90.0%、83.8%,联合用药组可明显改善证候,缓解临床症状,改善镜下胃粘膜形态,临床治疗效果明显优于对照组,统计学有显著性差异。结论:兰索拉唑联合中药治疗湿热中蕴型急性胃黏膜病变的疗效明显优于单一用药治疗,应加强对联合用药指征、用法、疗程的深入研究,以确保联合用药的合理性和有效性。

Abstract: Objective:To investigate the clinical effect of lansoprazole combined with traditional Chinese medicine for treating damp-heat stasis in the middle-jiao of acute gastric mucosal lesion.Methods:Ninety patients were randomly divided into control groups ( two groups)and treatment group (one group).Each group has 30 cases. The treatment group took lansoprazole and herbs, the control group 1 took lansoprazole, the control group 2 took herbs.The clinical effects of the three groups were compared.Results:The total effective rate of the treatment group was higher than that of the control groups (93.6% vs 63.3% 74.2%, P<0.05), there was statistical significance between the data. Combination therapy can obviously improve the syndromes, relieve the clinical symptoms, improve gastric mucosal morphology.Conclusion:The efficacy of lansoprazole combined with traditional Chinese medicine can be effective in the treatment of damp-heat stasis in the middle-jiao of acute gastric mucosal lesion, which should strengthen the in-depth study of syndrome, usage, course of treatment of combination therapy, in order to ensure the rationality and validity of the combined use of drugs.