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10种中药注射剂联合NP治疗非小细胞肺癌的网状Meta分析

田金徽,赵晔,李金龙,葛龙,杨克虎   

  1. 兰州大学循证医学中心,甘肃 兰州 73000,兰州大学循证医学中心,甘肃 兰州 73000,兰州大学循证医学中心,甘肃 兰州 73000,兰州大学循证医学中心,甘肃 兰州 73000,兰州大学循证医学中心,甘肃 兰州 73000
  • 收稿日期:2014-08-02 修回日期:2014-08-02 出版日期:2015-02-25 发布日期:2015-01-25

Chinese Herb Injections Combined with NP for Non-small Cell Lung Cancer:A Network Meta-analyses of 167 randomized controlled trials

  1. Evidence based medicine center of Lanzhou University,,,,
  • Received:2014-08-02 Revised:2014-08-02 Online:2015-02-25 Published:2015-01-25

摘要: [] 目的 采用网状Meta分析评价10种中药注射剂联合GP(吉西他滨和顺铂)治疗非小细胞肺癌(non-small cell lung cancer,NSCLC)的价值。方法 检索11个中外文数据库,同时检索在研研究和相关学术组织网站,补充其他检索获取所有中药注射剂联合NP治疗NSCLC的随机对照试验(randomized controlled trial,RCT),按预先制定的纳入与排除标准筛选和纳入,并对纳入RCTs的质量进行质量评价,数据采用WinBugs软件进行分析。结果 纳入10种中药注射剂,167个RCTs。网状Meta分析结果显示:以NP为共同干预措施,华蟾素注射液 NP、鸦胆子油乳注射液 NP和艾迪注射液 NP分别与得力生注射液 NP在生活质量方面的差异有统计学意义,鸦胆子油乳注射液 NP与得力生注射液 NP,复方苦参注射液 NP、康莱特注射液 NP和艾迪注射液 NP分别与华蟾素注射液 NP、康艾注射液 NP和鸦胆子油乳注射液 NP在恶心呕吐方面的差异有统计学意义,康莱特注射液 NP与鸦胆子油乳注射液 NP,鸦胆子油乳注射液 NP和康艾注射液 NP分别与华蟾素注射液 NP在白细胞减少方面的差异有统计意义,在有效率方面,10种中药注射剂之间的差异无统计学意义。结论 网状Meta分析结果提示,以NP为共同干预措施,得力生注射液、参芪扶正注射液和鸦胆子油乳注射液较其他7种中药注射液相对有效。

Abstract: []Objective:To the assess the clinical effects and safety of Chinese herb injection(CHI) combined NP for Non-small Cell Lung Cancer(NSCLC) based on the same comparison .Methods:The relative randomized controlled trials (RCTs) of CHI injections were searched from eleven database. the related references and website were also traced. The RCTs were screened according to the predefined inclusion and exclusion criteria, the related items were used to assess the quality of RCTs, data were analyzed by WinBugs software.Results:167 RCTs and ten CHI injections were finally included..the results of network meta analysis showed that,combined with NP,there were significant difference between huachansu injection or yadanzyouru injection or aidi injection and delisheng injection in quality of life,yadanziyouru injection and delisheng injection,compound matrine injection or kanglaite injection or aidi injection and huachansu injection or kang’ai injection or yadanaiyouru injection in nausea and vomiting,kanglaite injection and yadanziyouru injection,kang’zi injection or yadanziyouru injection and huachansu injection in leukopenia.,there was no difference between ten CHI injections in efficacy.Conclusion:Based on the results of network meta analysis, delisheng injection,shengqifuzhe injection and yadanziyouru injection was more than other seven CHI injections based on the common intervention .