Abstract: Objective: To compare the similarity of dissolution curves of dipyridamole tablets from the original drug enterprise and domestic enterprises, and provide the basis for a comprehensive evaluation of the quality of domestic dipyridamole tablets. Methods: The dissolusion and dissolution curves of the original drug enterprise and 6 domestic enterprises were ditermined on the basis of the “Chinese Pharmacopoeia” 2010 edition, the similarity was compared by the calculation of f1 and f2 factors using the product from the original enterprise as the reference preparation, and the domestic products as the test preparation. Results: Accordance with the standard of the “Chinese Pharmacopoeia” 2010 edition,the dissolution of the reference preparation and the test preparation comply with the requirements;Similarity factor was evaluated,the disslution curves of the same batch of test preparation exhibited obvious differences, and there was no similarity between the test preparation and the reference preparation by the methods of f1 and f2 factors. Conclusion: The similarity factor evaluation method can effectively reflect and control the intrinsic quality of the product, instruct manufacturers to improve production processes and product quality.