Abstract: Objective :To establish a method for the determination of 4 residual solvents including methonal, acetone,tert-Butanol,n-butanol in Atorvastatin calcium raw material. Methods:Headspace capillary GC method was adopted. The determination was performed on DB-624 capillary column at the rate of 5.0mL/min using helium gas as carrier gas and FID as the detector by temperature programming(initial column temperature of 40 ℃，maintaining for 3 min，then raising to 150 ℃ at a rate of 15 ℃/min，maintaining for 2 min，and then descending to 40 ℃ at a rate of 30 ℃/min，maintaining for 8 min). The temperature of the injector was maintaining at 180 ℃ and that of detector at 260 ℃. The split ratio was 2:1.The equilibrium temperature was 100 ℃ and equilibrium time was 30 min. The looper temperature was 100 ℃ and the The transmission pipe temperature was 110 ℃.The volume of sample was 2 mL. Results:The measured 4 residul solvents were separated completely under given chromatogram systems. The calibration curve of ezch solvent showed a good linear relationship with precision and recovery. Conclusion:The method is specific, reliable sensitive,and suitable for the content determination of residual solvents in Atorvastatin calcium raw material.