Abstract: Objective： In order to provide reference for improving the rational use of antibacterial agents and promoting hospital information construction.Methods： According to basic information construction， the rational use of antibacterial agents has been monitored， which is combining with the program of national special rectification action of antibacterials. Usage rate and intensity of antimicrobial agents was extracted and comparative analyzed in outpatient， emergency and hospitalization from 2013-2014 by information management system.Then the effect of system on the rational use of antibacterial agents was assessed.Results： Informational management systems play a role in promoting and improving the special rectification of antibacterial agents in our hospital. The usage ratio of antibacterial-agents in outpatient and emergency was 13.40% and 38.09% respectively in 2013， and the usage rate and DDDs of antibacterial agents was 56.90%、40.23 DDDs. Meanwhile， the usage ratio in outpatient and emergency was 11.15% and 35.14% in 2014 respectively， and the usage rate and DDDs was 55.42% and 38.80 DDDs， respectively in hospitalization.Conclusion：The use of antibacterial agents has improved in general from 2013 to 2014， and information management system can effectively enhance the level of antibacterial agents use and improve the efficiency of pharmacy management.