Abstract: [Abstract]In the history， human used several ways， such as mosquito nets， screens， witchcraft， Chinese herbal medicine and other traditional ways， and due to the curative effect of cinchona bark， human find quinine and chloroquine， later， the pesticide DDT and artemisinin drugs also can be found. All of them played an important role to control the spread of malaria. This paper is overviewed how many treatments and methods which by human used and found， and its development is also prospected.