Abstract: [Abstract]Objective：To analyze characteristics and rules of adverse drug reaction(ADR)of psychiatric hospital inpatients in our hospital， and to improve the safety and guide clinical rational drug use of psychotropic medicines.Methods： A retrospective study was carried out for a period from January 2014 to September 2015 and a total of 190 cases ADR were reported to the National Adverse Drug Reaction Monitoring system during the study period.Results：190 cases ADR female patients (n=116， 61.05%)were more than the male（n=74， 38.95%）.The age group of 15～29(n=81， 42.63%)were predominated. The most common drugs associated with the ADR were risperidone (n=41， 21.58%)， valproic acid (n=38， 20.00%) and quetiapine (n=17， 8.95%).The systems most commonly involved in ADR were nervous system (n=68， 35.79%) in which mainly associated with extrapyramidal side effects， gastrointestinal tract (n=25， 13.16%) and hemic and lymphatic system (n=19， 10.00%).Most ADR had presented within 0～7d（n=70， 36.84%）of the initiation of psychotropic agents therapy.The results of ADRs showed improved(n=102， 53.68%) or cured (n=79， 41.58%)， 8 unknown(4.21%)， 1 unimproved (0.53%).Of the reported reactions， causality assessment showed 59.47% of the ADR were definite（n=113）， 25.79% were probable（n=49）， 14.21% were possible (n=27) and 0.53% were unlikely(n=1).Conclusion：There are common side effects associated with psychotropic agents， which mainly affect the nervous system.Interventions on ADR that focus on prevention， early identification， accurate diagnosis and appropriate interventions can improve the safety of psychotropic medicines.