姜黄素对A549裸鼠移植瘤影响的网状Meta分析

姜黄素对A549裸鼠移植瘤影响的网状Meta分析

杨佳卉,张雅婷,唐佳,沈克非,王万聪,陈卿斌,黄鹏,田金徽

兰州大学循证医学中心，兰州大学基础医学院,,,,,,,

收稿日期:2016-07-17 修回日期:2016-07-17 出版日期:2016-08-25 发布日期:2016-08-25
基金资助:
]甘肃省循证医学与临床转化重点实验室开放基金；兰州大学中央高校基本科研业务专项资金资助(lzujbky-2015-170;lzujbky-2014-18)

Network Meta-analysis of the effects of Curcumin on human lung adenocarcinoma A549 xenografted tumor in nude mice

Evidence-based Medicine Center,School of Basic Medical Sciences,Lanzhou University,Gansu Lanzhou,Evidence-based Medicine Center,School of Basic Medical Sciences,Lanzhou University,Gansu Lanzhou,Evidence-based Medicine Center,School of Basic Medical Scienc

Received:2016-07-17 Revised:2016-07-17 Online:2016-08-25 Published:2016-08-25

摘要/Abstract

摘要： 目的：评价姜黄素对A549裸鼠移植瘤影响。方法：系统检索主要中文数据库,纳入数据库中有关姜黄素对A549裸鼠移植瘤影响的动物实验,采用SYRCLE动物实验风险评估工具评价纳入研究质量,STATA13.0软件对数据进行合并分析。结果：共纳入7个研究,网状Meta分析结果显示,与空白相比姜黄素能够减轻瘤重,缩小肿瘤体积,降低肿瘤微血管密度,在姜黄素基础上,加用顺铂可以增加疗效。结论：姜黄素对A549肺癌细胞裸鼠移植瘤的生长具有明显抑制作用。

Abstract: ［］ Objective: To assess the effect of curcumin on human lung adenocarcinoma A549 xenografted tumor in nude mice. Methods: We searched major Chinese database.The animal studies of curcumin on human lung adenocarcinoma A549 xenografted tumor in nude mice were included,the quality of included studies were assessed by SYRCLE’s risk of bias tool, and the related data were analyzed by STATA 13.0 software. Results: The seven studies were included, the network Meta-analysis showed that, compared with the no treatment, curcumin could reduce the mean volume and weight of the xenografted tumor, and decrease microvessel density,at the same time, curcumin combined with cisplatin could increase the effect. Conclusion: The current evidence showed that curcumin could significantly effects on human lung adenocarcinoma A549 xenografted tumor in nude mice.

杨佳卉,张雅婷,唐佳,沈克非,王万聪,陈卿斌,黄鹏,田金徽. 姜黄素对A549裸鼠移植瘤影响的网状Meta分析[J]. .

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