奈达铂和顺铂同步放化疗治疗中晚期宫颈癌的临床疗效观察

奈达铂和顺铂同步放化疗治疗中晚期宫颈癌的临床疗效观察

李志玖,燕平,艾淑颖,王道梅

湖北医药学院附属太和医院,湖北医药学院附属太和医院,湖北医药学院附属太和医院,湖北医药学院附属太和医院

收稿日期:2016-06-12 修回日期:2016-06-12 出版日期:2016-08-25 发布日期:2016-08-25

Observasion of the Clinial Efficacy between Nedaplatin and Cisplatin Concurrent Chemoradiotherapy in the Treatment of Advanced Cervical Carcinoma

燕平,艾淑颖 and 王道梅

Department of Oncology ,Taihe Hospital ,Hubei University of Medicine，hubei ,shiyan,Department of Oncology ,Taihe Hospital ,Hubei University of Medicine，hubei ,shiyan,Department of Oncology ,Taihe Hospital ,Hubei University of Medicine，hubei ,shiyan,Depart

Received:2016-06-12 Revised:2016-06-12 Online:2016-08-25 Published:2016-08-25

摘要/Abstract

摘要： 目的探讨奈达铂和顺铂联合放疗治疗晚期宫颈癌的临床疗效和毒副反应。方法 82例晚期宫颈癌患者随机分为2组，奈达铂同步放化疗组（治疗组）和顺铂同步放化疗组（对照组），每组41例。结果治疗组合对照组有效率、生存率比较差异均无统计学意义（P>0.05），但治疗组胃肠道反应、肾功能损害发生率低于对照组，而治疗组的血小板减少发生率高于对照组，差异有统计学意义（P<0.05）。结论治疗组和对照组有相似的疗效，不良反应可以耐受。

Abstract: To investigate the clinical efficacy and toxicities of nedaplatin and cisplatin concurrent chem-oradiotherapy in the treatment of advanced cervical cancer. Method Eight-two patients with advanced cervical cancer were randomly divided into the two groups,concurrent chem-oradiotherapy with nedaplatin group(the treatment group) and concurrent chem-oradiotherapy with cisplatin group(the control group), 41 cases in each group. Results There was no statistial difference in the response rate and the survival rate between the two groups（P>0.05）.The incidences of gastrointestinal reaction and renal dysfunction in the treatment group were lower than those in the control group（P<0.05）,while the incidence of thrombopenia in the treatment group were higher than those in the control group（P<0.05）. Conclusion The similar anti-tumor efficacy was observed between nedaplatin and cisplatin in the concurrent chemoradiotherapy of advanced cervical Carcinoma, while the nedaplatin has the lower and more acceptable side-effects.

李志玖,燕平,艾淑颖,王道梅. 奈达铂和顺铂同步放化疗治疗中晚期宫颈癌的临床疗效观察[J]. .

燕平,艾淑颖 and 王道梅. Observasion of the Clinial Efficacy between Nedaplatin and Cisplatin Concurrent Chemoradiotherapy in the Treatment of Advanced Cervical Carcinoma[J]. .

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