Abstract: ［］ Objective: To assess the existing problems on labeling contents of drug instructions for Children in China,which may be help to promote the improvement and standardization of contents of labeling contents. Methods: The major Chinese database were searched, the study on the the labeling contents of drug instructions for Children were included. The related data were analyzed by STATA 13.0 software,at the same time,subgroup analysis was performed by dosage forms.Results: Thirty-six studies were included with a total sample size of 13213.The Meta-analysis showed that for all related items, the missing rate of pharmacological toxicology, clinical trials and the safety of medicines using is all very high. The rate of pharmacokinetics without annotation is 61%.The description of drug interactions and drug overdose unclear are 24% and 36%.The rate of contraindications with clear annotation is less than 5%,for precautions is just 33%. The usage and dosage such as annotations were not clear or follow the doctor"s advice,the rate are 17% and14%. The rate of usage and dosage with no dose of children using is 21%.Conclusion: The labeling contents of drug instructions for Children were missing or insufficient, which may be affect the safety of using medicines for children.