Abstract: Objective： To investigate the clinical efficacy and safety of the flurbiprofen axetil combined with dexmedetomidine to prevent remifentanil-induced hyperalgesia. Methods： 80 cases of female patients who underwent laparoscopic cholecystectomy from January 2016 to June 2016 in our hospital were selected and randomly divided into control group， flurbiprofen axetil group， dexmedetomidine group and combination group. After drug intervention， VAS scores at postoperative 1， 2， 6， 12， 24h， additional analgesics within 24h after surgerywere and adverse reaction conditions were recorded and compared. Results： The VAS scores of each time point of the combined treatment group were significantly lower than that of the single drug group and the control group. The number of agitation cases of the dexmedetomidine group and the combination group was significantly lower than the control group. The incidence of additional analgesic drugs in the combined medication group was significantly lower than that of the other three groups in the groups（P<0.05）. Conclusion： The flurbiprofen axetil combined with the dexmedetomidine can reduce the incidence of hyperalgesia after remifentanil anesthesia effectively. At the same time， the incidence of additional analgesics drugs and agitation was significantly decreased， and the effect was better than that of the single drug.