Abstract: Objective： To discuss the clinical effect of using atropine in patients with organophosphate poisoning.Methods： In our hospital patients as the research object in 100 cases of organophosphorus in January 2015-2016 year in March，and were randomly divided into control group and observation group. The control group was treated with intravenous injection between the way for the medicine，the observation group was treated with continuous intravenous infusion of the way to medicine.The cure rates of the two groups were compared， and the length of hospital stay and the time of atropine.Results： The cure rate of observation group was 96%， and the cure rate was 70% in the control group， there were significant differences between the two groups（P<0.05）， have statistical significance. To observe the dose of atropine and atropine used time and hospitalization time of patients were better than the control group，there is significant difference between the two groups was statistically significant（P<0.05）.Conclusion： The organic phosphorus of patients in clinical treatment， the use of atropine for continuous intravenous administration of atropine，can effectively reduce the time and improve the cure rate of patients，but also reduce the dosage of atropine and hospitalization time of patients，is worthy of promotion in clinical use.