Abstract: Objective: To Investigation outpatient pediatric respiratory tract infections in children with the use of antibiotics in our hospital to promote the rational use of antibiotics. METHODS A retrospective analysis of October 2016 in our hospital pediatric outpatient respiratory tract infections in children with a total of 28069 visitors antibiotic usage. RESULTS Upper respiratory tract infection and lower respiratory tract infections, respectively 42.01% (7380/17569) and 79.16% (8312/10500) people use antibiotics, respectively, 21.12% (3711/17569) and 70.27% (7378/10500) intravenous antibiotics. Upper and lower respiratory tract infections oral combined with intravenous antibiotics usage was 1.37% (241/17569) and 12.58% (1321/10500). Upper and lower respiratory tract infections are the third generation cephalosporin oral antibiotic usage, accounting for 76.6% (2995/3910) and 67.85% (1530/2255), respectively, the upper and lower respiratory tract infections intravenous antibiotics for the highest rate of penicillin and large lactone ring, accounting for 36.67% (1361/3711) and 21.09% (1556/7378). CONCLUSION Outpatient pediatric respiratory infection rate is relatively high use of antibiotics, antibiotics should be strictly controlled non-standard applications, and effectively improve the rationality and safety of children medication.