精神科1916例药品不良反应/事件分析

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精神科1916例药品不良反应/事件分析

盛鑫,叶明全,童九翠,杭荣华,程旻

皖南医学院,皖南医学院,皖南医学院弋矶山医院临床药学部,皖南医学院,芜湖市第四人民医院

收稿日期:2017-05-02 修回日期:2017-05-20 出版日期:2017-08-25 发布日期:2017-08-25
基金资助:
国家自然科学基金（61672386）；教育部人文社会科学研究规划基金（16YJAZH071）；安徽省自然科学基金（1708085MF142,1308085MH126）

Analysis of 1916 Cases of Psychiatry Adverse Drug Reaction /Events Reporting

童九翠, and

Wannan Medical College,Wannan Medical College,Wannan Medical College,Anhui Wuhu,Wannan Medical College,The th People’s Hospital of Wuhu

Received:2017-05-02 Revised:2017-05-20 Online:2017-08-25 Published:2017-08-25

摘要/Abstract

摘要： 目的：探讨精神科常用药品不良反应/事件(ADR/ADE)发生的特点与规律，为临床合理用药提供依据。方法：对芜湖市第四人民医院2012～2016年收集并上报的ADR/ADE报告1916例，按照性别与年龄、药品种类、累及系统-器官及临床表现、合并用药和转归情况进行统计分析。结果：1916例ADR/ADE报告中，18～30岁青年人较多， 584例（占30.50%）；涉及药品29种，以抗精神病类药品引起ADR/ADE最多，报告1665例（占86.90%），ADR/ADE报告中药品奥氮平最多，820例（占49.24%）；ADR/ADE累及系统为神经系统较多，701例（占35.67%）。结论：应继续加强精神科ADR/ADE的监测工作，通过对ADR/ADE的分析加强药品合理规范使用，为临床精神科医生用药提供参考。

Abstract: Objective: Exploring the characteristics and general pattern of the psychiatric adverse drug reaction / Events (ADR/ADE) to provide scientific basis for clinical rational use of drugs. Methods: 1916 ADR/ADE cases collected in The 4th People’s Hospital of Wuhu from 2012 to 2016 were analyzed statistically in terms of patients'' gender and age, drug category, involving system-organs, clinical manifestations, drug combination and outcome. Results: Among 1916 cases of ADR/ADE reports, young people aged from 18 to 30 took up the highest proportion, around 584 cases (30.50%); involving 29 kinds of drugs, ADR/ADE caused by antipsychotics were in the first place, accounting for 1665 cases (86.90%), and olanzapine was the most commonly mentioned in reports, around 820 Cases (49.24%); The most involved system of ADR/ADE was nervous system, 701 cases were reported (35.67%). Conclusion: We should continue to strengthen the monitoring work of ADR/ADE, and regulate the rational use of drugs by analyzing ADR/ADE, which can provide references for clinical psychiatrists.

盛鑫,叶明全,童九翠,杭荣华,程旻. 精神科1916例药品不良反应/事件分析[J]. .

童九翠, and. Analysis of 1916 Cases of Psychiatry Adverse Drug Reaction /Events Reporting[J]. .