Abstract: Objective： To provide reference for rational clinical application of tiopronin injection by analyzing the regularity of its adverse drug reactions (ADR)， the related influencing factors and the prevention and treatment measures. Methods： We reviewed the literature by searching the database published in Chinese from 1989 to 2015， and 115 adverse drug reactions reports were included in this analysis according to patient information， medication information and literature information. Results： Most patients experiencing adverse drug reactions were males which accounting for 73.04%. 52.17% patients with ADR were at age between 41 and 60. 63.48% patients with ADRs occurred in 30 minutes after injection， and 99.13% of the patients got recovered or exhibited better prognosis， but 1 patient died eventually. There were 46.09% patients had unknown allergy history records. Conclusion： There were various clinical symptoms of ADRs and allergic reaction was the most significant one. The major potential risk factor that may be related to ADRs included male gender and elder age. Our study suggested that some factors， such as gender， age， allergy history， drug administration speed and concentration， drug combination should be taken into consideration when administration of tiopronin to be rational used andensure the safety of the patient′s medication.