Abstract: Objective：To analyze the general patterns and characteristics of nervous system adverse reactions induced by levofloxacin lactate and sodium chloride injection and provide reference for clinical medication. Methods：To search the CNKI literature base，VIP database，conducted summary analysis on the 11 cases of nervous system adverse reactions induced by levofloxacin lactate and sodium chloride injection case literatures domestic publicly reported from January 2000 to February 2018. Results：A total of 11 adverse drug reactions(ADR) were identified and analyzed，more cases in males than in females.Patients over the age of 50 years showed the highest incidence.Most of the reasons for the use of the drug are upper respiratory tract infection.The main ADR of nervous system are insomnia，visual hallucination and phonism.The symptoms improved or disappeared in 4 cases， the others were cured or improved after treatment.There was no death case. Conclusion：Levofloxacin lactate and sodium chloride injection induced ADR of the central nervous system should be watched，and strengthen monitoring on drug use so as to reduce the incidence of ADR.