Abstract: 【】 Objective：To assess the efficacy of Shen Kang injection in the treatment of diabetic nephropathy or chronic renal failure by overview the systematic reviews, at the same time, to analysis cost-effectiveness of the Shen Kang injection in the treatment of diabetic nephropathy or chronic renal failure. Methods：We electronically searched databases including CNKI, WanFang Data, VIP, CBM, PubMed, Embase and The Cochrane Library to collect systematic reviews or Meta-analyses about Shen Kang injection for diabetic nephropathy or chronic renal failure from inception to June 18, 2018.Two reviewers independently screened literatures, extracted data, and then AMSTAR tool was used to assess the methodological quality of included studies. Meanwhile, the cost-effectiveness analysis was used to compare the economic exhaustion of Shen Kang injection combined with conventional treatment and conventional treatment. Results：A total of 8 systematic reviews/Meta-analyses were included. The quality of systematic reviews/Meta-analyses were good, the item 1 of “Was an ‘a priori’ design provided” was not reported in the 8 systematic reviews/Meta-analyses. The results of overview showed that: compared with the conventional treatment, the conventional treatment combined Shen Kang injection or the conventional treatment combined Shen Kang injection combined alprostadil could improve the clinical efficacy in the treatment of diabetic nephropathy or chronic renal failure.as for cost-effectiveness, compared with conventional treatment, the treatment period was 2 weeks, Shen Kang Injection combined with conventional treatment can reduce the serum creatinine (Scr) and the usea nitrogen (BUN); the treatment period was 4 weeks or longer, Shen Kang Injection combined with conventional treatment can reduce the serum creatinine and the urea nitrogen in patients with CRF, increased glomerular filtration rate (GFR), and need to pay the corresponding cost. Conclusion: compared with the conventional treatment, the clinical efficacy of combination with Shen Kang Injection and conventional treatment is slightly higher, but the effect is better.