Abstract: Objective： To analyze the results of the concentration of sodium valproic acid， in order to provide a basis for clinical and clinical medication. Methods： Retrospectively analyzed on 85 cases of valproate blood drug concentration monitoring results from January to November 2017， using SPSS 20.0 statistical software analysis of blood drug concentration distribution and gender， age， dosage forms， drug combination for the effects of valproate blood drug concentration. Rusults： Statistical analysis of monitoring results， the blood concentrations less than 50 μg·mL-142 cases (49.41%)， the effective drug concentration range (50 to 100 μg·mL-1) in 41 cases (48.24%)， the result is more than 100 μg·mL-1 in 2 cases (2.35%). Patients in the study of gender， age， valproate formulations and drug combination of blood drug concentration had no statistical significance， the influence of patients daily dose and blood drug concentration showed individual differences. Conclusion Patient blood concentrations of valproic acid sodium with dose exist individual differences， on the application of valproate treatment of epilepsy， should according to patients with clinical manifestations， blood drug concentration monitoring results in a timely manner to adjust doses， implement individualized dosage， improve drug efficacy， to ensure clinical medication safety.