Abstract: Objective：To select the dissolution test method for thecefaclor capsulesand research the stabilities ofcefaclorsolution. Methods： We compared the dissolution profilesof cefaclor capsules， measured by UV(264 nm) in different conditions。 Results： The Ceclor shows a better dissolution trend with the Rotating Basketsmethod(50 r·min-1) than others. It performs significant dissolution trendin the mediumsof water and pH 4.0， and high solubility in the mediums of pH 1.2 and pH 6.8. Butin the pH6.8 medium， the ceclorshowsless than 90%dissolution at lastbecause ofdegraded probably. The results ofsolution stabilities of API indicates thatcefaclor is already degraded in 15min only in pH 6.8 medium， and can reach 46% degradationafter 2 h. No significant degradation was found in other mediums. Conclusion： We preferred the Rotating Baskets method(50 r·min-1) as the dissolution profilesmethod of cefaclor capsules in the Quality and Efficacy Agreement Evaluation of Generic Drug. And thesamples should not be placed for a long time because of its degradation in pH6.8 medium.