Abstract: ]Objective：To evaluate dissolution rate and its uncertainty in ciprofloxacin hydrochloride tablets measurement. Methods： Risk analysis of the measurement uncertainty will be made on the bases of calculated uncertainty components according to the influential elements that have been analyzed by means of measurement ways of dissolution rate of ciprofloxacin hydrochloride tablets on the fourth part of China pharmacopoeia 2015. Results： The average result of dissolution rate is 86.3% with the expanded uncertainty rate is 2.3%(k=2) in the experiment. The qualified rate of the dissolution rate is 100 %， but there are more results approaching to the limit. Conclusion： Uncertainty analyses and evaluation will be made when experimental results are reaching to or nearly limits， this will be able to ensure the rationality scientificity of the measurement， which will contribute to the promotion and improvement of pharmaceutical production.