Abstract: Objective：To analyze the usage of special class antibacterial agents in a hospital， and provided a reference for clinical rational drug use. Methods： To collect the usage of special class antibacterial agents in a hospital from 2016 to 2017 and analyzed retrospectively. All data were analyzed statistically on basis of the criteria of evaluating by given DDD，DDDS，DDC and the rate of usage and use intensity. Results： From 2016 to 2017， the highest of DDC in the hospital was the injectedvoriconazole( ￥896) in 2016， the highest of DDC in the hospital was the linezolid injection( ￥857.13) in 2017，the highest of DDS in the hospital was the injected meropenemin 2016， the highest of DDS in the hospital was the injected meropenem and Ceftriaxone tazobactam in 2017.From 2016 to 2017， the highest of the rate of usage and use intensity was ICU. Conclusion： In the period of investigation， the structure of special class antibacterial agents usage was basically reasonable. We can basically know about the usage of special class antibacterial agents in a hospital from 2016 to 2017， it can be used as a reference for the management of special class antimicrobial agents in hospitals.