Abstract: To establish and validate the method for determining the dissolution of artemether and lumefantrinein the artemether and lumefantrinedispersible tablets.Methods： For artemether， using 1 000 mL of degassed water as the dissolution medium， and rotating the paddle at 100 revolutions per minute. At 60 minutes and 180 minutes withdraw a sample of 10 mL of the medium through an in-line filter as test solutions. Using a stainless steel column (12.5 cm×40 mm) packed withparticles of silica gel which has been modified with chemically bonded octadeylsilyl groups (Macherey-Nagel，Nucleosil 100-5 was recommended). As the mobile phase， use a mixture of 400 volumes of water， 500 volumes of acetonitrile 100 volumes of 1-propanol and 1 volume of trifluoroacetic acid.Operate with a flow rate of 1 mL per minute. As a detector using an ultraviolet spectrophotometer was set at a wavelength of about 210 nm.For lumefantrine， using 1000 ml of hydrochloric acid (~3.6 g·L-1) TS， 1% benzalkonium chloride Ras the dissolution medium， and rotating the paddle at 100 revolutions per minute. At 45 minutes withdraw a sample of 10 ml of the medium through an in-line filter.Allow the filtered sample to cool to room temperature. Measure the absorbance of a 1 cm layer of the resulting solution， suitably diluted if necessary， at the maximum at about 342 nm. For each of the six tablets tested， calculate the total amount of lumefantrine (C30H32Cl3NO) in the medium， using the absorptivity value of 300.8(A1%1 cm=300.8). Results：The dissolution of artemether at 1 hour and 3 hours wasabove58.5% and 85.9%， respectively； Lumefantrinewas dissolved above 82.8% at 45 minutes. Conclusion：The methods to determine the dissolution of artemether and lumefantrinein the artemether and lumefantrine dispersible tablets， and which is accurate， high in stability and strong in specificity.