Abstract: Objective： This study aims to optimize the types of Changyanning granule excipients， improve the taste of this product， which make it more acceptable to patients， and improve the compliance of clinical medication， thereby increasing the compliance of patients with medication. Methods： Through screening experiments on different excipient combinations of Changyanning Granules， the way of adding excipients was optimized to adjust the taste of the product. Results： After optimization， dextrin， lactose and sucralose were used as flavor modifiers to reduce the amount of lactose. Sucralose was selected as flavor modifier to adjust the taste of the product. After adjustment of adjuvants， the volume of granules was 2 g per bag. Conclusion： After adjusting the excipients， the production process is easier to control， the sweetness and bitterness of the product are increased， the taste of the product is improved， the faction and taste of the product are more acceptable to children patients， and the compliance of clinical medication can be improved without increasing the total amount of excipients taken.