Abstract: Objective： To investigate the influence of butyphthalide combined with atorvastatin on nerve function in patients with acute cerebral infarction. Methods： 92 patients with acute cerebral infarction who admitted in the hospital from July 2017 to June 2018 were selected as the subjects. All patients were randomly divided into control group and combined group， with 46 cases in each group. Control group was given atorvastatin based on routine treatment (thrombolysis， anti-platelet aggregation， improving circulation， nourishing brain cell)， while combined group was treated with butyphthalide injection based on control group. The curative effects of two groups were compared. The venous blood was taken before treatment and after treatment for 14d， the levels of IL-6 and CRP were detected， and the adverse reactions were compared between the two groups. Results： The total effective rate of combined group was higher than that of control group； After treatment， the NIHSS score， IL-6 and CRP in combined group were lower than those before treatment and control group， and the above differences were statistically significant (P＜0.05). The total incidence of adverse reactions in combined group was slightly higher than that in control group， but the difference was not statistically significant (P>0.05). Conclusion： Butyphthalide combined with atorvastatin in treatment of patients with acute cerebral infarction is safe and effective， which can significantly improve nerve function and reduce inflammatory response.