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中国药物评价 ›› 2022, Vol. 39 ›› Issue (2): 186-188.

• 药品评价 • 上一篇    

瑞戈非尼致血小板减少1

魏瑞娜12,李淑芳12*   

  1. 1.河南大学附属肿瘤医院药学部,河南 郑州 450000;          2.郑州市第三人民医院药学部,河南 郑州 450000

  • 收稿日期:2021-09-09 修回日期:2021-11-16 出版日期:2022-04-28 发布日期:2022-04-28
  • 基金资助:
    河南省医学科技攻关计划联合共建项目(LHGJ20200721)

A Case of Thrombocytopenia Caused by Regorafenib in Rectal Cancer

  1. 1. Department of Pharmacy, Cancer Hospital of Henan University, Henan Zhengzhou 450000, China;         2. The Third Peoples Hospital of Zhengzhou, Henan Zhengzhou 450000, China

  • Received:2021-09-09 Revised:2021-11-16 Online:2022-04-28 Published:2022-04-28

摘要:

分析1例晚期直肠癌患者使用瑞戈非尼后出现重度血小板减少的诊疗经过,通过文献分析,阐述瑞戈非尼致血小板减少的原因。在升血小板的治疗过程中,应根据患者的体重足量足疗程的使用促血小板生成素(rhTPO),最终患者血小板缓慢提升,病情趋于稳定。


关键词: 瑞戈非尼, 直肠癌, 血小板减少, 促血小板生成素(rhTPO)

Abstract:

The process of diagnosis and treatment of a patient with severe thrombocytopenia in the course of treatment of advanced rectal cancer by regorafenib was analyzed. Through literature review and analysis,the main causes of thrombocytopenia induced by regorafenib were described. An enough dose and course of treatment of rh-TPO should be given on the basis of the patient′s weight in the treatment of thrombocytopenia. Eventually, the patient′s condition stabilized.


Key words: Regorafenib, Rectal cancer, Thrombocytopenia, RhTPO

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