关键词: 气相色谱仪-质谱联用仪（GC-MS）, 环氧氯丙烷, 3-氯丙烯

Abstract: Objective： To establish a specific method of the genetic toxicity impurity 3-chloropropene in epichlorhydrin. Methods： The chromatographic column was Agilent DB-624UI， the carrier gas was helium， the flow rate was 1.23 mL·min-1， the inlet temperature was 250 ℃， and the column temperature was programmed to increase. The Vials was incubated at 100 ℃ for 30 min. The electron impact ionization method was used， and the ion source temperature was 230 ℃. The quantitative determination was carried out using the SIM mode. Results： 3-chloropropene showed a good linear relationship within the concentration range of 1.044-52.20 ng·mL-1 (r=0.999 8). The detection limit and the quantification limit were 0.522 0 and 1.044 ng·mL-1， respectively， and the sample recoveries was 94.13%. Conclusion： The method is good in separation effect， convenient and highly sensitive. It can be used to monitor the quality of epichlorhydrin products.

Key words: Gaschromatography-mass spectrometry（GC-MS）, Epichlorhydrin, 3-chloropropene