关键词: font-size:medium, ">慢性阻塞性肺疾病；呼吸衰竭；喜炎平注射液；无创呼吸机通气；肺功能；炎症

Abstract: Objective： To investigate the effect of Xiyanping injection combined with noninvasive ventilator ventilation on pulmonary function and serum inflammatory mediator levels in patients with chronic obstructive pulmonary disease (COPD) accompanied by type Ⅱ respiratory failure. Methods： A total of 150 COPD patients accompanied by type Ⅱ respiratory failure admitted to our hospital from August 2021 to October 2024 were selected. Patients were divided into two groups according to a random number table method. Each group has 75 cases. The control group received conventional treatment plus non-invasive ventilator ventilation， while the observation group received Xiyanping injection in addition to the control group. The clinical efficacy， pulmonary function [forced expiratory volume in one second (FEV1)， forced vital capacity (FVC)， peak expiratory flow rate (PEF)]， blood gas analysis indicators [arterial partial pressure of carbon dioxide (PaCO2)， arterial partial pressure of oxygen (PaO2)， arterial oxygen saturation (SaO2)， pH value]， serum inflammatory mediator levels [white blood cell count (WBC)， procalcitonin (PCT)， soluble myeloid cell triggering receptor-1 (sTREM-1)， C-reactive protein (CRP)]， and adverse reactions were compared between the two groups. Results： The total effective rate of the observation group was 92.00%， which was higher than that of the control group (78.67%) (P<0.05). There was no significant difference in adverse reactions between the groups (P>0.05). After treatment， the FEV1， FVC， and PEF in the observation group were all higher than those in the control group (P<0.05). After treatment， PaCO2 in both groups was decreased， while PaO2， SaO2， and pH were increased. The improvement was more significant in the observation group (P<0.05). Compared with the control group， the WBC， PCT， sTREM-1， and CRP levels in the observation group were lower after treatment (P<0.05). Conclusion： The effect of Xiyanping injection combined with non-invasive ventilator ventilation in the treatment of COPD patients accompanied by type Ⅱ respiratory failure is significant. It can not only effectively improve lung function and blood gas analysis indicators， but also reduce inflammatory reactions and is safe.

Key words: font-size:medium, ">Chronic obstructive pulmonary disease； Respiratory failure； Xiyanping injection； Non-invasive ventilator ventilation； Pulmonary function； Inflammation